Antibiotic Combined Hyperimmune Serum Therapy for Peste des Petits Ruminants Infected Goats

Abstract

The peste des petits ruminants (PPR) has now been recognized as endemic viral disease associated with high morbidity and mortality rates in goats of Bangladesh. As there is no known effective drug against viral diseases, an attempt was made to evaluate the efficacy of antibiotic combined hyperimmune serum therapy (ACHST) against the deadly viral disease, PPR in goats. Naturally PPR infected 128 goats were randomly selected and used for this trial experiment in six different goat farms during the period from March 2001 to July 2003. The distribution of animals were 38 at the BLRI Goat Isolation Shed, Savar, 31 at Military Goat Farm, Savar, 14 at Bangladesh Missionary Farm, Sripur, 11 at the Olympia Goat Farm, Savar, 23 at the Globe Goat Farm, Kaliakoir and 11 at the Islam Nagar Goat Farm, Savar, and each of the selected goat was injected with specific hyperimmune serum @ 10 ml / goat IV daily for 3 days and oxytetracycline @ 1 ml / 10 kg body weight IM twice at 48 hours intervals, which resulted 78.94%, 70.97%, 57.14%, 63.64%, 60.87%, 63.64% and 68.75% recovery rates respectively with an average of 68.75%. The comparative evaluation of ACHST at different stages of naturally PPR infected goats showed highest recovery rate in incubation period (90.63%), followed by prodromal (78.13%), pneumonic (73.33%) and lowest in diarrhoeal (46.93%) phases. It may be concluded from these results that ACHST could be used as therapeutic measures for PPR infected goats.

Key words: Goat; PPR; antibiotic; hyperimmune serum; therapy

DOI = 10.3329/bjvm.v1i1.1918

Bangl. J. Vet. Med. (2003). 1(1) : 49 - 51