Bangladesh Journal of Pharmacology <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor. <br />The author will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free. We do not publish any advertisement.</p> <p><strong>Journal Metrics</strong><br />Journal metrics allow you to compare journals, regardless of their subject classification.<br />Impact Factor<sup>®</sup> as reported in the 2021 Journal Citation Reports<sup>®</sup>: <strong>1.143</strong></p> <h2><img src="" alt="" /></h2> <p>CiteScore (2021): <strong>2.0</strong> <a href="">Current month's CiteScore Tracker</a><br />H index (2021): <strong>26 </strong>(It means 26 articles of this journal have more than 26 number of citations)</p> <p>We have more than 10,000 readers from South Korea to Nigeria.</p> <p><strong>Abstracted/Indexed in</strong><br />Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, <a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br />Bangladesh Journal of Pharmacology is the member of <a href="">OASPA</a> (Open Access Scholarly Publishers Association), <a href="">COPE</a> (Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> en-US <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li class="show">Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="" target="_new"><span style="color: #337755;">Creative Commons Attribution License</span></a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li class="show">Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li class="show">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a href="" target="_new"><span style="color: #337755;">The Effect of Open Access</span></a>).</li> </ol> (Mir Misbahuddin) (Md Fahmid Uddin Khondoker) Mon, 06 Jun 2022 02:56:10 +0000 OJS 60 Anti-inflammatory activity of Memecylon malabaricum <p>NA</p> Ravindra Gaikwad, Sameer Nadaf, Anilkumar Shinde Copyright (c) 2022 Ravindra Gaikwad, Sameer Nadaf, Anilkumar Shinde Mon, 06 Jun 2022 00:00:00 +0000 Antiproliferative effect of Memecylon malabaricum leaves methanolic extract against A-431 cell lines <p>NA</p> Ravindra Gaikwad, Anilkumar Shinde Copyright (c) 2022 Ravindra Gaikwad, Anilkumar Shinde Mon, 06 Jun 2022 00:00:00 +0000 Sesquiterpene compound α-cyperone relieves the injury in neurons undergoing oxygen-glucose deprivation/reoxygenation <p>The present study aimed to explore the effects of α-cyperone, an extract of <em>Cyperus </em><em>rotundus, </em>on PC12 cells, as well as the underlying mechanism. Following the cells were induced by oxygen-glucose deprivation/reoxygena-tion (OGD/R), the viability, morphology, inflammation, oxidative stress and apoptotic levels in the cells were evaluated. To explore the mechanism of α-cyperone, cells were treated with 3-TYP, a sirtuin-3 (SIRT3) inhibitor, and then the effects of 3-TYP on the function of α-cyperone were assessed. α-Cyperone was found to reduce OGD/R-induced damage to neuronal viability and alleviate inflammation, oxidative stress, and apoptosis. In addition, α-cyperone could elevate SIRT3 and decline acetyl-forkhead box O1 (FOXO1) levels, and 3-TYP broke the effects of α-cyperone on the aforementioned aspects in the PC12 cells. In conclusion, α-cyperone activated SIRT3 and FOXO1 deacetylation, and alleviated OGD/R-induced cell inflammation, oxidative stress, and apoptosis.</p> Jian Wang, Xuefeng Gao Copyright (c) 2022 Jian Wang, Xuefeng Gao Mon, 06 Jun 2022 00:00:00 +0000 Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera <p>This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of <em>Euphorbia </em><em>resinifera </em>in mice<em>. </em>Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. <em>E. resinifera</em> reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α<sub>2</sub>, 5HT<sub>2</sub>, D<sub>2</sub>, and GABA<sub>A</sub> receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.</p> Majda Badaoui, Soad Moubtakir, Chafik Terrafe, Rachida Aboufatima, Abderrahman Chait Copyright (c) 2022 Majda Badaoui, Soad Moubtakir, Chafik Terrafe, Rachida Aboufatima, Abderrahman Chait Mon, 06 Jun 2022 00:00:00 +0000 Inhibitory effect of AK-7 mediates by apoptosis, increases DNA fragmentation and caspase-3 activity in human glioblastoma multiforme cells <p>Sirtuins (SIRTs) which are nicotinamide adenine dinucleotide (NAD+) dependent class III histondeacetylases have a controversial role in cancer. In this study, the effect of pharmacological inhibition of AK-7, a SIRT2 inhibitor, was investigated in U87 glioblastoma multiforme cells. The cytotoxic effect of AK-7 was evaluated by XTT analysis. After AK-7 treatment, colony forming capacity of cells was determined and apoptosis was evaluated. The expression levels of apoptosis-related genes were determined by qRT-PCR. According to the results, AK-7 inhibited cell proliferation in a dose- and time-dependent manner. After AK-7 treatment, the colony forming capacity of U87 cells was suppressed. And, AK-7 increased apoptosis rate, DNA fragmentation, and caspase-3 activity. According to qRT-PCR, a significant increase was observed in expression levels of apoptosis-related genes. This study revealed that AK-7 inhibits cell proliferation and induces apoptosis in glioblastoma multiforme cells and SIRT2 inhibition can be evaluated as a therapeutic approach in glioblastoma multiforme.</p> Ebru Güçlü, İlknur Çınar Ayan, Hasibe Vural Copyright (c) 2022 Ebru Güçlü, İlknur Çınar Ayan, Hasibe Vural Mon, 06 Jun 2022 00:00:00 +0000 Medroxyprogesterone acetate improves propionic acid-induced autism rat model and magnetic resonance spectroscopic correlation <p>The protective effect of medroxyprogesterone acetate on propionic acid-induced autism in rats was evaluated. For this purpose, 30 rats were divided into three groups. The significant difference in the levels of IL-17 (p&lt;0.05), IL-2 (p&lt;0.05), and TNF-α (p&lt;0.05), lactate (p&lt;0.05), and nerve growth factor (p&lt;0.05) were found in the medroxyprogesterone-treated group by biochemical analysis. In histopathological examination, the medroxyprogesterone-treated group revealed significant improvement in neural body degeneration, neural count, and dysmorphological changes in both CA1 and CA3 regions. Immunohistochemical examination revealed improvement in glial activity with glial fibrillar acidic protein and morphological changes in Purkinje cells. Magnetic resonance spectroscopy showed an improvement in the level of lactate duplets in the medroxyprogesterone-treated group. To our knowledge, this is the first study, to evaluate the protective effect of medroxyprogesterone on propionic acid-induced autism in rats.</p> Mehmet Fatih Bozkurt, Muhammad Nasir Bhaya, İbrahim Halil Sever, Bahattin Özkul, Oytun Erbaş Copyright (c) 2022 Mehmet Fatih Bozkurt, Muhammad Nasir Bhaya, İbrahim Halil Sever, Bahattin Özkul, Oytun Erbaş Thu, 16 Jun 2022 00:00:00 +0000