Bangladesh Journal of Pharmacology <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the&nbsp;<a href="">Bangladesh Pharmacological Society</a>&nbsp;(BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor.&nbsp;</p> <p>The author&nbsp;will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free.</p> <p><strong>Journal Metrics</strong><br>Journal metrics allow you to compare journals, regardless of their subject classification.</p> <p>Impact Factor&nbsp;(2014): 1.052 (Web of Science)</p> <p><a href="">CiteScore Tracker 2019</a>: Updated on April 30, 2019</p> <div style="height: 100px; width: 180px; font-family: Arial, Verdana, helvetica, sans-serif; background-color: #ffffff; display: inline-block;"> <div style="padding: 0px 16px;"> <div style="padding-top: 3px; line-height: 1;"> <div style="float: left; font-size: 28px;"><span id="citescoreVal" style="letter-spacing: -2px; display: inline-block; padding-top: 7px; line-height: .75;">0.71</span></div> <div style="float: right; font-size: 14px; padding-top: 3px; text-align: right;"><span id="citescoreYearVal" style="display: block;">2018</span>CiteScore</div> </div> <div style="clear: both;">&nbsp;</div> <div style="padding-top: 3px;"> <div style="height: 4px; background-color: #dcdcdc;"> <div id="percentActBar" style="height: 4px; background-color: #007398;">&nbsp;</div> </div> <div style="font-size: 11px;"><span id="citescorePerVal">24th percentile</span></div> </div> <div style="font-size: 12px; text-align: right;">Powered by &nbsp;<img style="width: 50px; height: 15px;" src="" alt="Scopus"></div> </div> </div> <p><strong>Abstracted/Indexed in</strong><br>Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts,&nbsp;<a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate,&nbsp;Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br>Bangladesh Journal of Pharmacology is the member of&nbsp;<a href="">OASPA</a>&nbsp;(Open Access Scholarly Publishers Association),&nbsp;<a href="">COPE</a>&nbsp;(Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> Bangladesh Pharmacological Society en-US Bangladesh Journal of Pharmacology 1991-0088 <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li class="show">Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="" target="_new"><span style="color: #337755;">Creative Commons Attribution License</span></a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li class="show">Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li class="show">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a href="" target="_new"><span style="color: #337755;">The Effect of Open Access</span></a>).</li> </ol> Effect of cock’s comb extract in the treatment of palmar arsenical keratosis <p class="Abstract">The aim of this study was to examine the effect of cock’s comb extract in the treatment of moderate palmar arsenical keratosis (n = 35). All the patients were provided cock’s comb extract ointment to apply topically twice daily for 12 weeks. Adherence to the ointment and adverse effects were monitored regularly through the phone call and during the visit of each patient. Photographs of both palms were collected before and after treatment. Clinical improvement was assessed by measuring the arsenical keratotic nodular size of the both palms before starting the treatment and after completion of the treatment. The mean (± SD) sizes of the nodules before the study was 33.6 ± 16.8, which reduced to 5.4 ± 5.2 after completion of the study. This change (84% reduction) was statistically significant. None of the patients reported to any adverse effect during this study period. In conclusion, cock’s comb extract can be used effectively as a topical treatment of the palmar arsenical keratosis.</p> <p>&nbsp;</p> Fatema Chowdhury Anny Mir Misbahuddin ##submission.copyrightStatement## 2019-05-07 2019-05-07 14 2 87 92 10.3329/bjp.v14i2.38421 Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract <p>The present study investigates the effect of ludartin on spinal cord injury in rat model. Ludartin treatment decreased the expression of myeloperoxidase and malondialdehyde in spinal cord tissues. The expression of glutathione and superoxide dismutase was enhanced. It also exhibited inhibitory effect on reduction of NeuN-positive cells. The proportion of TUNEL positive cells was also regulated. In addition, ludartin treatment prevented the onset of apoptosis which was evident by decrease in caspase-3 and Bax level and increase of Bcl‑2 level. Up-regulation of tumor necrosis factor‑α, inter-leukin‑1β and I interleukin‑6 by spinal cord injury was suppressed by ludartin treatment. There was improvement in locomotion of rats by treatment with ludartin. Ludartin treatment of spinal cord injury rats improves locomotion by inhibiting inflammatory cytokine expression and preventing cell apoptosis. Thus, ludartin has therapeutic importance in spinal cord injury treatment.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Western Blot Analysis: 6 min 17 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp; &nbsp; &nbsp; <a href="">Alternate</a></p> Jae Sung Pyo Hyung Hoi Kim Kang Min Kim Jae Seon Kang ##submission.copyrightStatement## 2019-04-07 2019-04-07 14 2 61 66 10.3329/bjp.v14i2.39034 In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera <p class="Abstract">The anti-diabetic effect of <em>Atractylis gummifera</em> (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of <em>A. gummifera</em> was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal.</p> <p class="Abstract"><strong>Video Clip of Methodolpogy</strong>:</p> <p class="Abstract">5 min 53 sec:&nbsp; &nbsp;<a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a></p> Khadija Bouabid Fatima Lamchouri Hamid Toufik Mohamed Boulfia Souad Senhaji My El Abbes Faouzi ##submission.copyrightStatement## 2019-04-14 2019-04-14 14 2 67 73 10.3329/bjp.v14i2.38870 Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice <p>The aim of the present study was to evaluate the hypoglycemic potential of <em>Trixis angustifolia</em> in alloxan-induced diabetic mice. An intragastric administration of the aqueous extract (50, 100 and 200 mg/kg) prepared from the aerial parts of <em>T. angustifolia</em> was evaluated. The treatment with the extract at 100 mg/kg produced a significant lowered (30.5%) of the blood glucose levels in diabetic mice after 15 days of daily oral administration. In addition, the extract induced a significant decrease in serum total cholesterol, low density lipoprotein whereas increased the high-density lipoprotein level. Additionally, the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars were identified in the extract. These findings provide a basis explaining the traditional folk medicine use of this plant as a hypoglycemic agent by the Mexican people.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>5 min 16 sec:&nbsp; &nbsp;<a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a></p> Anuar Salazar-Gómez María Elena Vargas-Díaz Leticia Garduño-Siciliano ##submission.copyrightStatement## 2019-04-21 2019-04-21 14 2 74 79 10.3329/bjp.v14i2.39254 Stellaria media attenuates the hyperglycemia and hyperlipidemia in alloxan-induced diabetic rat <p><strong>Abstract</strong></p> <p>The objective of this research work was to assess the hyperglycemic and hyperlipidemiceffects of <em>Stellaria media</em> in alloxan induced diabetic rats using different experimental models. Standard documented protocols were used to concede the <em>in vitro</em> and <em>in vivo</em> activities. Biochemical markers studies were also done. The results of the study showed strong pancreatic α-amylase and β-glucosidase inhibition <em>in-vitro</em>at varying concentrations of the extract which further validated the <em>in-vivo</em> anti-diabetic action of the plant because of the inhibition of the above enzymes.The administration of various concentrations of the extract showedmomentous decrease in fasting blood level when compared to diabetic control. Similarly, remarkably improved hemoglobin (+20.10%), and decreased HbA1c (−48.44%) was observed when compared to diabetic control rats. The extract also caused reduced serum enzyme (ALT, ALP, bilirubin) levels and produced a succeeding recovery toward their normal values.It can be concluded from these investigations that the <em>in-vitro</em> and <em>in-vivo</em> hypoglycemic and hypolipidemic activity offers the methodicaljustification for the use of <em>S. media </em>in herb based anti-diabetic treatment.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Alpha-amylase inhibitory activity: 14 min 17 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp; &nbsp; &nbsp; <a href="">Alternate</a></p> Rahmat Khan Wasim Ahmad Mushtaq Ahmed ##submission.copyrightStatement## 2019-04-28 2019-04-28 14 2 80 86 10.3329/bjp.v14i2.39847 Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat <p>The present study was conducted to evaluate the nephroprotective effect of a medicinal herb <em>Costus pictus</em> against doxorubicin-induced toxicity. Rats were divided into six groups and treated with doxorubicin and ethanol extract of the <em>C. pictus</em>. Doxorubicin was administered intraperitoneally with a single dose (4 mg/kg) per week for three weeks. The extract (200 or 400 mg/kg) was administered orally for 4 weeks to two doxorubicin groups. Significant changes of the serum kidney markers, albumin, urea, uric acid and creatinine, and glutathione peroxidase, glutathione–S-transferase, catalase, superoxide dismutase, reduced glutathione and lipid peroxides in the kidney of doxorubicin-treated rat were observed. Histological features were also severely affected. However, biochemical and histological changes in the extract-treated rat were non-significant, showing that the herb is nephroprotective. The effects were comparable to the anti-oxidant vitamin E.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Histology Techniques: 12 min 6 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp; &nbsp; &nbsp; <a href="">Alternate</a></p> Muthiah Rajasekaran ##submission.copyrightStatement## 2019-05-14 2019-05-14 14 2 93 100 10.3329/bjp.v14i2.39992 Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model <p>This study was conducted to evaluate the topical efficacy of <em>Solanum incanum</em> for the treatment of partial-thickness burn in mice model. Mice were treated with topical ointment of <em>S. incanum</em> three times daily for 14 days. The wound healing was observed through wound contraction and histological parameters. The group treated with <em>S. incanum </em>ointment showed 81% reduction in wound area as compared to negative control where wound area reduced to 22%. The histological analysis further confirmed that ointment favors the tissue regeneration and reepithelization thus heal wound rapidly as com-pared to other groups. In conclusion, <em>S. incanum</em> extract enhances wound healing and tissue regeneration.</p> Zainab Qureshi Taous Khan Abdul Jabbar Shah Fazli Wahid ##submission.copyrightStatement## 2019-05-21 2019-05-21 14 2 101 106 10.3329/bjp.v14i2.40098 Hydrogen sulfide-mediated cardioprotection against ischemia reperfusion is linked to KATP channel for mitochondrial preservation but not for its distinct preference on interfibrillar mitochondria <p>Hydrogen sulfide has been shown to protect&nbsp; myocardium against ischemia-reperfusion injury by preserving interfibrillar mitochondria functional activi-ties than subsarcolemmal mitochondria. In this study, the role of the K<sub>ATP</sub> channel in modulating the mitochondrial subpopulations during the cardioprotection mediated by NaSH (H<sub>2</sub>S donor) was investigated. Isolated rat hearts were treated with mitochondrial K<sub>ATP</sub> channel closer glibenclamide (10 μM)/opener diazoxide (0.8 mM) via Langendorff perfusion apparatus before ischemia-reperfusion. The results showed that NaSH pre-conditioning in presence of glibenclamide significantly improved cardiac recovery without any significant difference between interfibrillar mitochondria and subsarcolemmal mitochondria.&nbsp; In conclusion, targeting K<sub>ATP</sub> channel may not be good option to target interfibrillar mitochondria/subsarcolemmal mitochondria against ischemia-reperfusion injury.</p> Priyadharshini Chandrasekaran Sriram Ravindran Sri Rahavi Boovarahan Gino A. Kurian ##submission.copyrightStatement## 2019-06-09 2019-06-09 14 2 107 115 10.3329/bjp.v14i2.39890