Bangladesh Journal of Pharmacology <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the&nbsp;Bangladesh Pharmacological Society&nbsp;(BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor.&nbsp;</p> <p>The author&nbsp;will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free. We do not publish any advertisement.</p> <p><strong>Journal Metrics</strong><br>Journal metrics allow you to compare journals, regardless of their subject classification.</p> <p>Impact Factor&nbsp;(2014): 1.052 (Web of Science)</p> <p><a href="">CiteScore Tracker 2019</a>: Updated on April 30, 2019</p> <div style="height: 100px; width: 180px; font-family: Arial, Verdana, helvetica, sans-serif; background-color: #ffffff; display: inline-block;"> <div style="padding: 0px 16px;"> <div style="padding-top: 3px; line-height: 1;"> <div style="float: left; font-size: 28px;"><span id="citescoreVal" style="letter-spacing: -2px; display: inline-block; padding-top: 7px; line-height: .75;">0.71</span></div> <div style="float: right; font-size: 14px; padding-top: 3px; text-align: right;"><span id="citescoreYearVal" style="display: block;">2018</span>CiteScore</div> </div> <div style="clear: both;">&nbsp;</div> <div style="padding-top: 3px;"> <div style="height: 4px; background-color: #dcdcdc;"> <div id="percentActBar" style="height: 4px; background-color: #007398;">&nbsp;</div> </div> <div style="font-size: 11px;"><span id="citescorePerVal">24th percentile</span></div> </div> <div style="font-size: 12px; text-align: right;">Powered by &nbsp;<img style="width: 50px; height: 15px;" src="" alt="Scopus"></div> </div> </div> <p><strong>Abstracted/Indexed in</strong><br>Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts,&nbsp;<a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate,&nbsp;Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br>Bangladesh Journal of Pharmacology is the member of&nbsp;<a href="">OASPA</a>&nbsp;(Open Access Scholarly Publishers Association),&nbsp;<a href="">COPE</a>&nbsp;(Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> Bangladesh Pharmacological Society en-US Bangladesh Journal of Pharmacology 1991-0088 <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li class="show">Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="" target="_new"><span style="color: #337755;">Creative Commons Attribution License</span></a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li class="show">Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li class="show">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a href="" target="_new"><span style="color: #337755;">The Effect of Open Access</span></a>).</li> </ol> Antibacterial activity of Weissella confusa by disc diffusion method <p>A visual experiment was conducted to investigate the antimicrobial potential of cell-free culture supernatant of <em>Weissella confusa</em> (DD_A7) against the foodborne pathogenic bacteria <em>Escherichia coli</em> 0157: H7 by disc diffusion method. The result revealed that DD_A7 exerted effective antibacterial potential to control the growth of <em>E. coli </em>upon treatment with 100 µg/mL of the culture supernatant. This study demonstrated that DD_A7 is a potent probiotic candidate to reduce the risk factor associated with Shiga toxin-producing <em>E. coli</em>.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Duration: 9 min 20 sec&nbsp; &nbsp;<a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a></p> Manigandan Krishnan Debasish Kumar Dey Chanchal Sharma Sun Chul Kang ##submission.copyrightStatement## 2019-07-07 2019-07-07 14 3 117 122 10.3329/bjp.v14i3.41545 Antimicrobial assay of endophytic fungi from Rumex madaio and chemical study of strain R1 <p>In order to search more antimicrobial natural products for new drug discovery, bioassay and chemical investigation of endophytic strains from <em>Rumex madaio</em> were carried out. Six fungal strains (numbered as L1, L6, L9, L10, R1, R2) were successfully isolated and their antimicrobial effects on three human pathogens, <em>Escherichia coli</em>,<em> Staphyloccocus aureus</em> and <em>Candida albicans</em>, were evaluated<em>.</em> The results indicated that ethyl acetate extracts of fermentation broth of these strains had no potent antimicorbial activity against <em>E. coli</em> and <em>C. albicans</em> while strains L1 and R1 had stronger inhibitory effects on <em>S. aureus</em>. On basis of morphological characteristics and 18<em>S</em> rRNA sequence analysis, strains L1 and R1 were respectively classified as <em>Colletotrichum </em>and <em>Fusarium</em> geni. The chemical study of strain R1 led to isolation of two known antimicrobial agents, dibutyl phthalate (<strong>1</strong>) and beauvericin (<strong>2</strong>).</p> <p><strong>Video Clip of Methodology:</strong></p> <p>1 min 14 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp; <a href="">Alternate</a></p> Xuelian Bai Ronglu Yu Mingzhu Li Huawei Zhang ##submission.copyrightStatement## 2019-08-07 2019-08-07 14 3 129 135 10.3329/bjp.v14i3.41598 Antidepressant-like activity of hydroalcoholic extract of Agaricus blazei in stressed and unstressed mice <p>The aim of this study was to investigate the antidepressant activity of hydroalcoholic extract <em>Agaricus blazei</em> (273 and 819 mg/kg; orally) in stressed and unstressed Swiss albino mice. Mice were immobilized to induce stress. Fluoxetine 20 mg/kg orally was given to stressed and unstressed animals and immobility time was noted by using forced swim test and tail suspension test. The concentration of plasma nitrite was also evaluated in stressed and unstressed mice. The effect of prazosin (α<sub>1</sub>-adrenoceptor antagonist), p-CPA (parachlorophenylalanine–tryptophan hydroxylase inhibitor) and 7-nitro-indazole (nNOS inhibitor) on the antidepressant activity of <em>A. blazei</em> was also evaluated. <em>A. blazei</em> and fluoxetine significantly decreased the duration of immobility time in stressed and unstressed mice, showing significant antidepressant activity. No substantial change was found in the locomotor activity. However, a significant reduction in the level of plasma nitrite was also noted in stressed mice. Hydroalcoholic extract showed prominent antidepressant activity in mice.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Forced swim test, Tail suspension test and Open field test:&nbsp;&nbsp; 4 min 17 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp; <a href="">Alternate</a></p> Israr ul Haq Muhammad Aslam Hammad Ahmed Nuzhat Sultana ##submission.copyrightStatement## 2019-08-14 2019-08-14 14 3 136 143 10.3329/bjp.v14i3.40803 Phytochemical analysis, cytotoxic, antioxidant and anti-diabetic activities of the aerial parts of Sorghum halepense <p>Phytochemical screening, cytotoxic activity, total phenolic content, antioxidant and anti-diabetic activities of the <em>Sorghum halepense</em>&nbsp;methanolic extract and its different fractions were evaluated.&nbsp;Methanolic extract and its various fractions revealed the presence of reducing sugars, tannins, steroids,&nbsp; glycosides, flavonoids in the methanolic extract where they were absent in n-hexane fraction except&nbsp;flavonoids.&nbsp;Gums and saponins were absent in all the samples. Methanolic extract indicated the highest cytotoxic (80.7 ± 1.3%) and anti-diabetic (62.5%) activities. The maximum total phenolic contents (28.7 ± 1.4&nbsp;mg/mL) were found in the chloroform fraction. An aqueous fraction expressed the highest antioxidant activity&nbsp;74.1 and&nbsp;97.1%&nbsp;free&nbsp;radical scavenging properties in DPPH and ABTS assays respectively&nbsp;whereas, in the case of&nbsp;H<sub>2</sub>O<sub>2</sub>, methanolic extract indicated maximum (36.9%) activity.&nbsp;In conclusion, the extract of aerial parts of <em>S.</em> <em>halepense&nbsp;</em>is a source of compounds against cancer, diabetic and free radical associated disorders.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>DPPH assay:&nbsp;&nbsp; 8 min 47 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp; <a href="">Alternate</a></p> Muhammad Abdur Rehman Shah Rahmat Ali Khan Mushtaq Ahmed ##submission.copyrightStatement## 2019-08-21 2019-08-21 14 3 144 151 10.3329/bjp.v14i3.40292 Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat <p>The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat. An integrated approach was used with the assessment of changes in the respirometric and antiapoptotic functions of mitochondria. It was found that the application of the objects under study contributed to a decrease in the intensity of glycolysis and the restoration of aerobic glucose metabolism with an increase in ATP synthesis, as well as a decrease in the dissociation of reactions in mitochondrial complexes I, II, IV and V. In addition, the introduction of the studied drugs reduced the intensity of caspase-dependent and caspase-independent apoptosis reactions, which, together with the restoration of mitochondrial respiratory function, contributed to the decrease in the size of the necrosis zone of the brain.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Rat middle cerebral artery occlusion: &nbsp; 8 min 7 sec &nbsp; <a href="">Full Screen</a> &nbsp; <a href="">Alternate</a></p> Pozdnyakov I. Dmitry Nygaryan A. Syranusch Voronkov V. Andrey Anastasya Sosnovskaya Cherechkova I. Elisaveta ##submission.copyrightStatement## 2019-08-28 2019-08-28 14 3 152 158 10.3329/bjp.v14i3.40977 Brine shrimp cytotoxicity potential of alpha-mangostin and dulxanthone D from Garcinia mangostana Kandasamy Sasikumar Asit Ranjan Ghosh ##submission.copyrightStatement## 2019-07-14 2019-07-14 14 3 123 124 10.3329/bjp.v14i3.41403 Anti-inflammatory effect of Actinia tenebrosa Komal Arvind Kumari Romil Champak Dagha Poonam Gautam Gawali Bhaskar Laxman Jadhav ##submission.copyrightStatement## 2019-07-21 2019-07-21 14 3 125 126 10.3329/bjp.v14i3.41472 Anticonvulsant activity of novel Schiff bases of thiadiazole derivatives Ajit Kumar Pandey ##submission.copyrightStatement## 2019-07-28 2019-07-28 14 3 127 128 10.3329/bjp.v14i3.41543