Bangladesh Journal of Pharmacology 2021-07-13T13:29:35+00:00 Mir Misbahuddin Open Journal Systems <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the&nbsp;Bangladesh Pharmacological Society&nbsp;(BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor.&nbsp;<br> The author&nbsp;will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free. We do not publish any advertisement.</p> <p><strong>Journal Metrics</strong><br> Journal metrics allow you to compare journals, regardless of their subject classification.<br>Impact Factor<sup>®</sup>&nbsp;as reported in the 2020 Journal Citation Reports<sup>®</sup>: <strong>0.930</strong></p> <p><strong><img src="/public/site/images/misbah/impact_2020.jpg" width="676" height="427"></strong></p> <p>CiteScore (2020):&nbsp;<strong>2.6</strong>&nbsp;&nbsp;<a href="">Current month's CiteScore Tracker</a><br> H index (2020): <strong>23</strong></p> <p>We have more than 10,000 readers from South Korea to Nigeria.</p> <p><strong>Abstracted/Indexed in</strong><br>Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts,&nbsp;<a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate,&nbsp;Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br>Bangladesh Journal of Pharmacology is the member of&nbsp;<a href="">OASPA</a>&nbsp;(Open Access Scholarly Publishers Association),&nbsp;<a href="">COPE</a>&nbsp;(Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> <h1 style="color: red;">Our activities are slow due to COVID-19 Lockdown</h1> Experimental models for vascular endothelial dysfunction 2021-07-01T13:29:11+00:00 Anchal Garg Vardan Gupta Ritu Tomar Mandeep Kumar Arora <p>Vascular endothelial dysfunction is characterized by apoptosis of endothelial cells, an imbalance between vasoconstrictory and vasodilatory substances, the imbalance between ROS and antioxidants, vascular remodeling, loss of vascular integrity which leads to an increased risk of cardiovascular complications. To date, no therapeutic intervention is available as a promising agent. This may be due to a poor understanding of the underlying mechanism involved in vascular endothelial dysfunction in the pathogenesis. Animal models sharing identical features as that of humans are paramount to understand fundamental physiology, mechanism and to explore new targets for developing therapeutic agents. Thus, it becomes mandatory to re-explore the available animal models for a better understanding of molecular pathways involving vascular endothelial dysfunction. The purpose of this paper is to review different models for vascular endothelial dysfunction to the outlook for developing new drugs to treat vascular endothelial dysfunction.</p> 2021-07-01T00:00:00+00:00 Copyright (c) 2021 Anchal Garg, Vardan Gupta, Ritu Tomar, Mandeep Kumar Arora Reintroduction of nitrofurantoin in the treatment of uncomplicated urinary tract infection 2021-07-03T13:29:14+00:00 Sabiha Mahboob Md. Sayedur Rahman <p>The present study was designed to reintroduce an older antimicrobial nitrofurantoin among a group of prescribers and to explore the relationship between the reintroduction and corresponding shift in sensitivity pattern of the microbes. The microbial sensitivity against ciprofloxacin before intervention was 46.6%, which significantly increased after intervention (51.8%). Treatment with nitrofurantoin resulted in a total clinical cure rate of 80.6%, of which rate of clinical cure achieved in expected time was 66.1% and delayed was 14.5%. The rate of total clinical cure with nitrofurantoin corresponded closely with the proportion of urinary isolates sensitive to nitrofurantoin. i.e., 86.3%. This preliminary study revealed that revival might be an effective strategy to increase the sensitivity and to delay the emergence of resistance.</p> 2021-07-03T00:00:00+00:00 Copyright (c) 2021 Sabiha Mahboob, Md. Sayedur Rahman Antibacterial activity of Cathormion umbellatum 2021-07-13T13:29:35+00:00 Surachai Rattanasuk Rujirek Boongapim Tannatorn Phiwthong <p>The aim of this study was to determine the antibacterial activity of <em>Cathormion umbellatum</em> extracts against seven antibiotic-resistant bacteria. The pods, leaves and branches of <em>C. umbellatum</em> were extracted with ethanol and methanol. The disc diffusion assay was used to screen the antibacterial activity and broth microdilution and colorimetric assay were used to measure the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The result indicated that the highest inhibition zone (11 mm) was presented in ethanolic pods extract against multidrug resistance <em>Klebsiella pneumoniae</em>. The lowest MIC value of 0.05 mg/mL was obtained from branch extracted with ethanol against colistin resistant <em>Pseudomonas aeruginosa</em>. The lowest MBC values of 1.56 mg/mL were obtained when using <em>C. umbellatum</em> leaves extracted with methanol against all test antibiotic-resistant bacteria. This is the first report presented <em>C. umbellatum</em> extracts have the potential to eliminate antibiotic-resistant bacteria in patients. These findings show the antibacterial effect of <em>C. umbellatum</em>.</p> 2021-07-13T00:00:00+00:00 Copyright (c) 2021 Surachai Rattanasuk, Rujirek Boongapim, Tannatorn Phiwthong Antibacterial activity of Dracaena lisa 2021-07-02T13:29:14+00:00 Saranya Shankar Mythili Sathiavelu 2021-07-02T00:00:00+00:00 Copyright (c) 2021 Saranya Shankar, Mythili Sathiavelu