Bangladesh Journal of Pharmacology

Effect of capecitabine on breast cancer patients with different estrogen receptor status

2020-06-09T11:59:06+00:00

This meta-analysis is to compare the efficacy of capecitabine versus non-capecitabine chemotherapy on breast cancer patients with different estrogen receptor (ER) status. We searched relevant literatures from EMBASE, PubMed and OVID library to analyze pathologic complete response rate (PCR), overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), and time to disease progression (TTP). Eleven different studies were enrolled, which revealed that ER positive breast cancer patients who received treatment regimen containing capecitabine can effectively improve PFS, PCR, TTP. However, the difference between capecitabine-containing and non-capecitabine group has no significant for DFS, OS. ER negative breast cancer patients who received treatment regimen containing capecitabine can obviously improve DFS and TTP. However, there was no significant effect for PFS, PCR and OS. The results indicated that capecitabine in combination with other chemotherapy drugs for breast cancer is effective, which can delay the progression time in patients to some extent.

Berberine hydrochloride inhibits inflammatory response via regulating the miRNA-140-5p/TLR4/NF-κB signaling pathway in oral lichen planus

2020-05-01T13:11:36+00:00

The present study investigates the anti-inflammatory mechanism of berberine hydrochloride in the oral lichen planus. The local inflammatory environment of the oral lichen planus was mimicked, through which lipopolysaccharides stimulated keratinocyte HaCaT cells. Berberine hydrochloride suppressed the activation of the TLR4/NF-κB inflammatory signaling pathway by up-regulating miRNA-140-5p, which is an independent risk factor for the oral lichen planus. Furthermore, miRNA-140-5p inhibited the TLR4/NF-κB inflammatory signaling pathway by directly suppressing TLR4 expression. Therefore, the present study suggests that berberine hydrochloride inhibits the inflammatory response by up-regulating miRNA-140-5p to suppress the activation of the TLR4/NF-κB inflammatory signaling pathway in the oral lichen planus.

Antimicrobial metabolites from Streptomyces sp. strain PDH23 derived from marine sponge Rhabdastrella globostellata

2020-05-13T14:20:00+00:00

Antibacterial activity of Dracaena colorama

2020-05-24T13:12:14+00:00