Bangladesh Journal of Pharmacology 2020-04-05T14:40:04+00:00 Prof. Mir Misbahuddin Open Journal Systems <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the&nbsp;Bangladesh Pharmacological Society&nbsp;(BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor.&nbsp;</p> <p>The author&nbsp;will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free. We do not publish any advertisement.</p> <p><strong>Journal Metrics</strong><br>Journal metrics allow you to compare journals, regardless of their subject classification.</p> <p>Impact Factor&nbsp;(2014): 1.052 (Web of Science)</p> <p><a href="">CiteScore Tracker 2019</a>: Updated on April 30, 2019</p> <div style="height: 100px; width: 180px; font-family: Arial, Verdana, helvetica, sans-serif; background-color: #ffffff; display: inline-block;"> <div style="padding: 0px 16px;"> <div style="padding-top: 3px; line-height: 1;"> <div style="float: left; font-size: 28px;"><span id="citescoreVal" style="letter-spacing: -2px; display: inline-block; padding-top: 7px; line-height: .75;">0.71</span></div> <div style="float: right; font-size: 14px; padding-top: 3px; text-align: right;"><span id="citescoreYearVal" style="display: block;">2018</span>CiteScore</div> </div> <div style="clear: both;">&nbsp;</div> <div style="padding-top: 3px;"> <div style="height: 4px; background-color: #dcdcdc;"> <div id="percentActBar" style="height: 4px; background-color: #007398;">&nbsp;</div> </div> <div style="font-size: 11px;"><span id="citescorePerVal">24th percentile</span></div> </div> <div style="font-size: 12px; text-align: right;">Powered by &nbsp;<img style="width: 50px; height: 15px;" src="" alt="Scopus"></div> </div> </div> <p><strong>Abstracted/Indexed in</strong><br>Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts,&nbsp;<a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate,&nbsp;Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br>Bangladesh Journal of Pharmacology is the member of&nbsp;<a href="">OASPA</a>&nbsp;(Open Access Scholarly Publishers Association),&nbsp;<a href="">COPE</a>&nbsp;(Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> Effects of tetracycline and clotrimazole ointments in the treatment of palmar arsenical keratosis 2020-04-02T14:38:04+00:00 Asiya Ferdous Mir Misbahuddin Abu Naser Ibne Sattar <p>The study was designed to see the effects of tetracycline and clotrimazole on the altered skin flora (<em>Aspergillus </em>and <em>Enterobacter </em>species) in 38 patients with palmar arsenical keratosis. The skin swab and scrapping samples were collected. Tetracycline, clotrimazole and their combination were given as ointment for 3 months. Clotrimazole and tetracycline were found to inhibit the growth of <em>Aspergillus</em> spp. and <em>Enterobacter</em> spp.<em> in vitro</em>. A pH-dependent inhibition of the growth of microorganisms in presence of these antimicrobials was observed, which was highest at pH 8. The percentage reduction of keratotic nodular size was 32.9, 66.1, 61.1 and 32.5 in the groups treated with placebo, tetracycline, clotrimazole and the combination of both, respectively. But none of the interventions was proved statistically significant. No remarkable adverse effect was reported. In conclusion, clotrimazole or tetracycline inhibits the growth of <em>Aspergillus</em> spp. or <em>Enterobacter</em> spp.<em> in vitro</em>. However, there was no statistically significant clinical improvement of the palmar arsenical keratosis.</p> 2020-03-08T05:26:16+00:00 ##submission.copyrightStatement## In vitro antiviral activity of BanLec against herpes simplex viruses type 1 and 2 2020-04-02T14:37:57+00:00 Arisha Taj Mahaboob Batcha Ashish Wadhwani Gowri Subramaniam <p>The present study evaluates the antiviral activity of banana lectin (BanLec) against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2). Lectin was isolated from the ripen pulp of bananas (<em>Musa paradisiaca</em>). The study showed that lectin exhibited hemagglutination activity towards human erythrocytes A, B, AB and O group. The molecular weight of BanLec using SDS gel-electrophoresis was found to be 14,000-30,000 Da. Cytotoxicity of BanLec on the Vero cell lines showed an inhibitory concentration of 172.7 µg/mL. BanLec was virucidal and showed no cytotoxicity at the concentration tested. The lectin showed a dose-dependent antiviral activities, inhibiting HSV-1 by 16.0 µg/mL with selectivity index 10.8 and HSV-2 inhibition by 67.7 µg/mL with selectivity index 2.6. These results corroborate that BanLec could be a rich source of potential antiviral compound for HSV-1 when compared to HSV-2.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Hemaglutination test: 11 min 29 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp;&nbsp;<a href=";">Alternate</a></p> 2020-03-08T14:00:00+00:00 ##submission.copyrightStatement## Antimicrobial activities of Allium staticiforme and Allium subhirsutum 2020-04-02T14:37:50+00:00 Alican Bahadir Semerci Dilek İnceçayır Vusale Mammadova Ayşegül Hoş Kenan Tunç <p>The antibacterial and antifungal activities of the bulb and flower of <em>Allium staticiforme</em> and <em>Allium subhirsutum</em> were investigated<em>. </em>In addition, DPPH radical scavenging activity and total phenolic contents were determined. The results show that methanolic extracts of <em>A. staticiforme </em>and <em>A. subhirsutum </em>had antifungal activities against <em>Candida albicans, t</em>ogether with a less activity level against <em>Escherichia </em><em>coli</em>, <em>Staphylococcus </em><em>epidermidis</em>, <em>S. aureus</em>, <em>Enterecoccus </em><em>faecalis, </em><em>Salmonella </em><em>typhimurium </em>and <em>Pseudomanas </em><em>aeruginosa</em>. The total phenolic contents of <em>A. staticiforme </em>leaf and bulb were determined as 17 and 2.4 mg of GAE/100 g, respectively. The IC<sub>50 </sub>of methanolic extracts of <em>A. staticiforme </em>and <em>A. subhirsutum</em> were also determined. In conclusion, both <em>A. staticiforme </em>and <em>A. subhirsutum </em>have antifungal activities with weak antibacterial activities. These plants have DPPH radical scavenging activities.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Disc Diffusion Method: 3 min 04 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp;&nbsp;<a href=";">Alternate</a></p> 2020-03-09T00:47:51+00:00 ##submission.copyrightStatement## Effects of shenkang injection on renal angiogenesis in mice with unilateral ureteral obstruction 2020-04-05T14:40:04+00:00 Yajing Pan Lu Zhang Tonghua Liu Lili Wu <p>This study aimed to investigate effects of shenkang injection on angiogenesis in mice with renal fibrosis. C57BL/6J mice after unilateral ureteral obstruction were administrated with different doses of shenkang injection for two weeks. Losartan-administrated mice and Sham-operation mice were as positive and negative controls, respectively. Renal function and vasculature changes were observed, and expressions of VEGF and VEGFR<sub>2</sub> were detected. Shenkang injection reduced serum levels of urea nitrogen, creatinine and cystatin C. Shenkang injection alleviated the loss of microvessels, decreased the deposition of collagen fibers, and increased expressions of VEGF and VEGFR<sub>2</sub> in the obstructed kidney. These findings indicate that shenkang injection alleviates renal dysfunction and fibrotic changes in mice with renal fibrosis by regulating renal angiogenesis.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Renal Vasculature by Angiography: 6 min 41 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp;&nbsp;<a href=";">Alternate</a></p> 2020-03-09T13:07:46+00:00 ##submission.copyrightStatement## Larvicidal, leishmanicidal, insecticidal and anthelmintic effects of Sterculia diversifolia stem bark and leaf 2020-04-05T14:39:56+00:00 Fazle Rabbi Amir Zada Amna Nisar <p>The present study was conducted to evaluate the stem bark and leaf of <em>Sterculia diversifolia </em>for larvicidal, leishmanicidal, insecticidal and anthelmintic activities. In the larvicidal activity, dichloromethane and ethyl acetate fractions of both stem bark and leaf showed significant results, while the ethyl acetate fraction showed mild activity (IC<sub>50</sub>: 70.09 ± 0.09 μg/mL; 71.25 ± 0.01 μg/mL). In the insecticidal activity of the stem bark,<em> n</em>-hexane fraction showed mild activity (20-40% mortality) against all three subjects, while the insecticidal activity of leaf, methanolic extract and <em>n</em>-hexane fractions showed moderate activity (60% mortality) against <em>Rhyzopertha dominica</em> and <em>Callosobruchus analis</em>. In the anthelmintic activity of stem bark and leaf, ethyl acetate fraction exhibited activity in a dose-dependent manner giving time of paralysis and death shorter followed by dichloromethane fraction with 200 mg/mL concentration<em>. </em>Hence, it is clear that <em>S. diversifolia </em>stem bark and leaf possess larvicidal, leishmanicidal, insecticidal and anthelmintic agents.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Anthelmintic Activity: 5 min 29 sec:&nbsp;&nbsp;<a href="">Full Screen</a>&nbsp;&nbsp;&nbsp;<a href=";">Alternate</a></p> <p>&nbsp;</p> 2020-03-10T13:26:36+00:00 ##submission.copyrightStatement## Effect of Garcinia indica against brain ischemic reperfusion in rat model 2020-04-05T14:39:50+00:00 Wasim Ahmed 2020-03-11T00:12:51+00:00 ##submission.copyrightStatement## In vitro antimutagenic activity of Ipomoea staphylina 2020-04-05T14:39:42+00:00 Amartya Banerjee Sayeed Mohammed Firdous Mumtaz 2020-03-11T00:36:19+00:00 ##submission.copyrightStatement## Anti-inflammatory and antifungal activity of Dracaena victoria leaf extract 2020-04-05T14:39:35+00:00 Ranjitha Dhevi V. Sundar Sathiavelu Arunachalam 2020-03-11T10:19:31+00:00 ##submission.copyrightStatement##