Bangladesh Journal of Pharmacology 2019-02-15T13:32:43+00:00 Prof. Mir Misbahuddin Open Journal Systems <p>Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, single blinded peer-reviewed journal of the&nbsp;<a href="/index.php/BJP/about/editorialPolicies#custom-0">Bangladesh Pharmacological Society</a>&nbsp;(BDPS). We publish Research article, Mini-review, Meta-analysis, Clinical Trial, Visual Experiment and Letter to the Editor.&nbsp;</p> <p>The author&nbsp;will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free.</p> <p><strong>Journal Metrics</strong><br>Journal metrics allow you to compare journals, regardless of their subject classification.</p> <p>Impact Factor&nbsp;(2014): 1.052 (Web of Science)</p> <p><a href="">CiteScore Tracker 2017</a>: Updated on April 7, 2018</p> <p><img src="/public/site/images/misbah/CiteScore2017_Bangladesh_Journal_o.png" alt=""></p> <p><a href="">ResearchGate Journal Impact</a>&nbsp;(2014): 1.84</p> <p><strong>Abstracted/Indexed in</strong><br>Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts,&nbsp;<a href="">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate,&nbsp;Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br>Bangladesh Journal of Pharmacology is the member of&nbsp;<a href="">OASPA</a>&nbsp;(Open Access Scholarly Publishers Association),&nbsp;<a href="">COPE</a>&nbsp;(Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="">ISMTE</a>) and Asian Council of Science Editors.</p> Efficacy and safety of regorafenib versus dinutuximab with chemotherapy in Chinese children with neuroblastoma 2019-02-15T13:28:59+00:00 Kun Dong Guan Wang Zeng Liang Wang Xueyan Wang <p>The objective of the present study was to evaluate the efficacy and safety of regorafenib in comparison with dinutuximab with chemotherapy in Chinese children with advanced neuroblastoma. The patients aged less than 16 years who were histologically diagnosed with advanced neuroblastoma were enrolled and randomized to receive either regorafenib plus best supportive care or dinutuximab plus chemotherapy plus best supportive care in a 1:1 ratio. The tumor response assessment was made in accordance with modified international neuroblastoma response criteria. Adverse events were also assessed. Regorafenib showed prolonged overall survival and progression-free survival than who received dinutuximab plus chemotherapy (overall survival: median 32.3 months versus 27.2 months; hazard ratio = 0.45; 95% CI 0.11-0.13, p&lt;0.001; progression-free survival: stratified hazard ratio = 0.48; 95% CI 0.11-0.14; p&lt;0.01).&nbsp; Moreover, the overall response rate was greater in patients treated with regorafenib as compared to dinutuximab group. Regorafenib appears efficacious and has a manageable safety profile in Chinese children with advanced neuroblastoma.</p> 2019-02-07T15:32:02+00:00 ##submission.copyrightStatement## A potential estrogen receptor inhibitor compound 34 induces apoptosis via ROS-independent intrinsic apoptosis in MCF-7 cells 2019-02-15T13:29:12+00:00 Ruru Ding Ziying Zhu Mengting Teng Lin Ma Jiaying Hu Jiangbiao Hu Peng Zhang <p>This study aimed to investigate the anti-tumor effects of compound 34 on MCF-7 cells in vitro, and explore its mechanisms. MTT results showed that compound 34 selectively inhibited estrogen receptor-positive cells proliferation. Hoechst 33342 staining showed nuclear pyknosis, nuclear debris associated with apoptotic bodies. JC-1 staining showed the loss of mitochondrial membrane potential. Although compound 34 increased intracellular reactive oxygen species (ROS), compound 34-induced apoptosis was not prevented by pretreatment with ROS scavengers. Western blotting showed apoptosis-related protein like cytochrome c and cleaved PARP protein increased. Furthermore, docking studies exhibited that compound 34 could bind into ERα. In summary, compound 34 selectively inhibited estrogen receptor positive cells proliferation and induced apoptosis in MCF-7 cells via ROS-independent intrinsic apoptosis in MCF-7 cells. It may be a potential targeted drug of estrogen receptor for therapeutic application of breast cancer.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Assay of Cell Proliferation: 5 min 5 sec&nbsp; &nbsp;<a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a>&nbsp;&nbsp;</p> 2019-01-07T08:09:18+00:00 ##submission.copyrightStatement## Wound healing effect of different extracts of Centaurea pterocaula 2019-02-15T13:29:09+00:00 Barış Ötün Ufuk Mercan Yücel <p>In this study, the effect of different extracts of <em>Centaurea pterocaula </em>were evaluated on 6 mm wound created by punch biopsy on the rat back. The leaves of the plant were powdered and extracted with distilled water, methanol, <em>n</em>-hexane and ethyl acetate. Extracts were obtained in the form of pomade with vaseline and applied topically to the wounds. The wound measurements performed on day 0, 2, 4, 6, 8, 10 and 12 and the histo-pathological examination performed on day 12. The <em>n</em>-hexane extract had an accelerating effect on wound healing and made a positive contribution to the healing process. In conclusion, <em>C. pterocaula </em>has a promising future for new drug development studies by its wound healing property.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>Wound healing assay: 2 min 52 sec: <a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a></p> 2019-01-14T00:56:04+00:00 ##submission.copyrightStatement## In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat 2019-02-15T13:29:05+00:00 Amel Bouaziz Seddik Khennouf Musa Abu Zarga Shtaywy Abdalla <p>The objective of this study was to evaluate the <em>in vitro</em> anti-oxidant, hypo-tensive and the diuretic activities of <em>Origanum glandulosum</em> leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3-methylphenol<em>.</em> Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of <em>O. glansulosum </em>in traditional medicine as hypotensive and diuretic agents.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>DPPH radical scavenging assay: 4 min 45 sec:&nbsp;<a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a></p> 2019-01-20T22:54:36+00:00 ##submission.copyrightStatement## Involving postgraduate medical students in pharmacology practical classes by e-learning 2019-02-15T13:29:02+00:00 Asma Akter Abbasy Mir Misbahuddin <p>The aim of the present study was to evaluate the effectiveness of e-learning (virtual class) in achieving procedural knowledge necessary to conduct practical class in the laboratory. In this study, teaching modules were prepared on eight selected topic related to pharmacology laboratory works. Virtual classes were conducted among the postgraduate MD students (n=26) of this Department. To know the existing procedural knowledge pre-test was taken before the classes and to evaluate the effectiveness of virtual class,&nbsp; a post-test was carried out seven days later. To get the feedback from students, two additional questionnaire surveys were done. The performance of each student improved in the post-test in comparison to the pre-test. Most of the students mentioned that virtual class was easier in comparison to face to face class. But they preferred combination classes to learn procedural knowledge.</p> 2019-01-27T23:33:43+00:00 ##submission.copyrightStatement## Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice 2019-02-15T13:32:43+00:00 Mozhgan Daneshkhah Mahbubeh Setorki <p>The purpose of this study was to investigate the effect of hydroalcoholic extract of <em>Artemisia</em> <em>persica</em> (100, 200 and 400 mg/kg) on pentylenetetrazole-induced seizure and memory impairment. Sixty mice were assigned to seven groups. Pentylenetetrazole (35 mg/kg) was injected at 48 hours intervals for 9 days, and at 60 mg/kg on day 10 to induce seizure model. Different doses of <em>A</em>. <em>persica</em> extract were injected daily 30 min before pentylenetetrazole injection. Exposure of mice to extract significantly reduced the frequency of repeated spinning and jumping and tonic seizures in seizure model. In addition, the extract significantly reduced the increased levels of malondialdehyde in serum and brain. The extract significantly increased the serum and brain anti-oxidant capacity but had no significant effect on nitric oxide. The extract (100 mg/kg) significantly improved pentylenetetrazole-induced memory impairment. The hydro-alcoholic extract of <em>A</em>.<em> persica</em> has a protective effect against pentylenetrazole-induced seizure.</p> <p><strong>Video Clip of Methodology:</strong></p> <p>1 min 56 sec:&nbsp;<a href="">Full Screen</a>&nbsp; &nbsp;<a href="">Alternate</a></p> 2019-02-14T01:01:54+00:00 ##submission.copyrightStatement##