TY - JOUR AU - Khan, Aslam AU - Rehman, Najeeb-ur- AU - AlKharfy, Khalid M. AU - Gilani, Anwarul-Hassan PY - 2011/10/14 Y2 - 2024/03/28 TI - Antidiarrheal and antispasmodic activities of Salvia officinalis are mediated through activation of K+ channels JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 6 IS - 2 SE - Research Articles DO - 10.3329/bjp.v6i2.9156 UR - https://www.banglajol.info/index.php/BJP/article/view/9156 SP - 111-116 AB - <p>This study was conducted to provide pharmacological basis for the medicinal use of <em>Salvia officinalis</em> in diarrhea. The crude extract of <em>S. officinalis</em> was studied using the <em>in vivo</em> and<em> in vitro</em> assays.  The crude extract inhibited castor oil-induced diarrhea in mice at the dose of 100 and 300 mg/kg. In isolated rabbit jejunum, it caused a dose-dependent (0.1-3 mg/mL) relaxation of spontaneous as well as low K<sup>+</sup> (25 mM) and high K<sup>+</sup> (80 mM)-induced contractions, being distinctly more potent on low K<sup>+</sup>. Pretreatment of tissue with 4-aminopyridine (1 mM) almost completely blocked the inhibitory effect of crude extract on low K<sup>+</sup>.  These results indicate that the crude extract of <em>S. officinalis</em> possesses antidiarrheal and antispasmodic activities mediated possibly through the dominant activation of voltage-dependent K<sup>+</sup> channels and this study provides sound pharmacological basis for its medicinal use in diarrhea and gut spasm.</p> ER -