TY - JOUR AU - Javeed, Maria AU - Rasul, Azhar AU - Hussain, Ghulam AU - Jabeen, Farhat AU - Rasool, Bilal AU - Riaz, Ammara AU - Kaukab, Ghazala AU - Ali, Muhammad PY - 2018/07/07 Y2 - 2024/03/28 TI - Harmine and its derivatives: Biological activities and therapeutic potential in human diseases JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 13 IS - 3 SE - Mini Review DO - 10.3329/bjp.v13i3.34990 UR - https://www.banglajol.info/index.php/BJP/article/view/34990 SP - 203-213 AB - <p>This review article aims to provide an update on the sources, pharmaco-logical and biological profile of a β-carboline alkaloid, harmine which is a major bioactive component of various plants mainly Peganum harmala. Harmine’s wide range of pharmacological properties has been well-documented as anti-cancer, anti-inflammatory, anti-oxidant, neuroprotective, anti-depressant, and antimicrobial. Although reported data suggests a multifunctional pharmacological role of harmine but farther experimentation on its molecular mechanism of action, synthetic chemistry approaches, and preclinical studies are yet obligatory to fully uncover its pharmacological efficacy.</p> ER -