TY - JOUR AU - Aslam, Muhammad AU - Sultana, Nuzhat PY - 2015/09/22 Y2 - 2024/03/28 TI - Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 10 IS - 4 SE - Research Articles DO - 10.3329/bjp.v10i4.23732 UR - https://www.banglajol.info/index.php/BJP/article/view/23732 SP - 753-758 AB - <p class="Abstract">The advantageous effects of <em>Vitis vinifera</em> juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. <em>V. vinifera</em> juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector.<em> V. vinifera</em> juice raised the levels of both serotonin (p&lt;0.001) and noradrenalin (p&lt;0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of <em>V. vinifera</em> juice against depressive disorders. Our results showed that<em> V. vinifera</em> juice could relieve depressive manifestations in the rodent model of depression.</p> ER -