TY - JOUR AU - Janbaz, Khalid Hussain AU - Saqib, Fatima PY - 2015/04/07 Y2 - 2024/03/28 TI - Pharmacological evaluation of Dactyloctenium aegyptium: An indigenous plant used to manage gastrointestinal ailments JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 10 IS - 2 SE - Research Articles DO - 10.3329/bjp.v10i2.21811 UR - https://www.banglajol.info/index.php/BJP/article/view/21811 SP - 295-302 AB - <p>Crude extract of <em>Dactylotenium aegyptium</em> and its fractions were evaluated to rationalize its folkloric use in gastrointestinal ailments. In spontaneous contracting rabbit jejunum preparation, D. aegyptium exert concentration-dependent spasmogenic effect (0.01-0.1 mg/mL) followed by spasmolytic effect at higher doses (0.3-3.0 mg/mL). Pretreatment of the tissue preparations with atropine resulted in suppression of the spasmogenic response. Furthermore, <em>D. aegyptium</em> (1.0 mg/mL) caused relaxation of K<sup>+ </sup>(80 mM)-induced spastic contractions in isolated rabbit jejunum preparations and there was non-parallel shift in Ca<sup>++</sup> dose response curves towards right (0.1-0.3 mg/mL). These findings were found to be comparable with verapamil, a standard Ca<sup>++</sup> channel blocker. The solvent-solvents fractionation reflected segregations of spasmogenic and spasmolytic effects in respective aqueous and dichloromethane fractions. The above-mentioned findings reflected, presence of cholinergic as well as Ca<sup>++</sup> channel blocking activity in ethanolic extract of <em>D. aegyptium</em> thus providing scientific basis for its folkloric use in constipation and diarrhea.</p> ER -