TY - JOUR AU - Haznedaroglu, M. Zeki AU - Gokce, Goksel PY - 2014/08/27 Y2 - 2024/03/28 TI - Zostera noltii extract lowers blood glucose and restores vascular function in diabetic rats JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 9 IS - 3 SE - Research Articles DO - 10.3329/bjp.v9i3.19437 UR - https://www.banglajol.info/index.php/BJP/article/view/19437 SP - 389-397 AB - <p>The antidiabetic effect of seagrass <em>Zostera noltii </em>extract was investigated through a crosstalk between its antioxidant and vasoprotective properties. The extract was orally administered to alloxan-diabetic rats (50, 150, 250 mg/kg body weight). Serum glucose was determined; liver and kidney functions, body weight, total leukocyte counts were measured; liver oxidative markers were assayed. Acetylcholine, phenylephrine and 5-HT responses were tested. eNOS levels and generation of ROS in aortic tissue were quantified. The extract of <em>Z. noltii</em> lowered blood glucose in all tested dose levels. Extract at a concentration of 50 mg/kg failed to preserve the levels of antioxidants and did not alter lipid peroxidation whereas higher doses improved liver oxidative status. Impaired acetylcholine relaxations, augmented phenylephrine and 5-HT contractions in alloxan-diabetic aortic rings were restored by <em>Z. noltii</em> treatment. This recovery was accompanied by increased eNOS synthesis and a reduction in ROS generation. The extract lowers blood glucose and prevents hyperglycemia-induced endothelial dysfunction in alloxan-diabetic rats.</p> ER -