TY - JOUR AU - Alamgeer, - AU - Nawaz, Mehwish AU - Ahmad, Taseer AU - Mushtaq, Muhammad Naveed AU - Batool, Asma PY - 2014/05/17 Y2 - 2024/03/28 TI - Hepatoprotective activity of Thymus linearis against paracetamol and carbon tetrachloride-induced hepatotoxicity in albino mice JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 9 IS - 2 SE - Research Articles DO - 10.3329/bjp.v9i2.18329 UR - https://www.banglajol.info/index.php/BJP/article/view/18329 SP - 230-234 AB - <p>In the present study, the hepatoprotective activity of aqueous and ether extracts of <em>Thymus linearis</em> (250 and 500 mg/kg orally) was evaluated against carbon tetrachloride- and paracetamol-induced hepatic damage in mice. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) were assessed. Antioxidant activity of both the extracts was also determined using 1-1-diphenyl-2-picryl hydrazine (DPPH) scavenging method. The results indicated that both the extracts significantly produce a dose dependent reduction in serum levels of ALT, AST, ALP when compared to carbon tetrachloride-and paracetamol-treated groups. The maximum effect in all the parameters was observed at a dose of 500 mg/kg. The extracts also demonstrated a significant antioxidant activity. LD<sub>50</sub> of both extracts was found to be a 1050 and 900 mg/kg respectively. It is conceivable that the hepatoprotective activity of <em>T. linearis</em> might be due to the presence of certain pharmacologically active compounds.</p> ER -