TY - JOUR AU - Bashar, Tahmina AU - Misbahuddin, Mir AU - Hossain, Md. Amir PY - 2014/01/20 Y2 - 2024/03/29 TI - A double-blind, randomize, placebo-control trial to evaluate the effect of Nigella sativa on palmar arsenical keratosis patients JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 9 IS - 1 SE - Clinical Trial DO - 10.3329/bjp.v9i1.17167 UR - https://www.banglajol.info/index.php/BJP/article/view/17167 SP - 15-21 AB - <p>This study was done to examine the role of <em>Nigella sativa</em> in 28 patients of palmar arsenical keratosis. Patients were randomized into two groups: Group A (n-15) receive capsules of placebo and vitamin E (200 mg) whereas Group B (n= 13) receive capsules of <em>N. sativa</em> oil (500 mg) and vitamin E (200 mg) orally for 8 weeks. The mean (± SD) clinical scoring of palmer arsenical keratosis in Group A before and after treatment was 99.3 ± 21.5 and 62.3 ± 14.3 respectively (37% reduction). On the other hand, in <em>N. sativa</em> oil treated group, the mean clinical score was 119.1 ± 20.3 before treatment which was reduced to 39.2 ± 8.4 (p&lt;0.0001) after treatment (67% reduction). There were 65% reduction of total arsenic in nail of Group A and 30% in Group B. In conclusion, oral administration of <em>N. sativa</em> oil improves the symptom of palmar arsenical keratosis as a result of reduction of body arsenic load.</p> ER -