TY - JOUR AU - Mazumder, Afjal Hussain AU - Das, Jayshree AU - Gogoi, Hemanta Kumar AU - Chattopadhyay, Pronobesh AU - Paul, Satya Bhusan PY - 2014/01/06 Y2 - 2024/03/28 TI - Antimicrobial activity of methanol extract and fractions from Sarcochlamys pulcherrima JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 9 IS - 1 SE - Research Articles DO - 10.3329/bjp.v9i1.16760 UR - https://www.banglajol.info/index.php/BJP/article/view/16760 SP - 4-9 AB - <p>Antimicrobial evaluation of methanol extract of <em>Sarcochlamys pulcherrima</em> leaf and its hexane, ethyl acetate, n-butanol and water fractions against 31 strains of microorganisms, using agar well, agar disc diffusion, and broth microdilution methods, revealed the activity of methanol extract against <em>Trichophyton mentagrophytes</em>, <em>Candida albicans</em>, <em>Staphylococcus aureus</em> and <em>Escheracia coli</em> (zone of inhibition: 21-40 mm, 200 mg/mL, and MIC: 6.25-50 mg/mL). All fractions also displayed antimicrobial activity (5-20 mg/mL), indeed ethyl acetate and n-butanol fractions showed better activity (MIC: 0.156 to 2.5 mg/mL). <em>C. albicans</em> was most sensitive to n-butanol fraction (15 mm, 2.5 mg/mL). Ethyl acetate and n-butanol fractions were more active against <em>T. mentagrophytes</em> (12 mm at 1.25 mg/mL) and <em>S. aureus</em> (ethyl acetate-16 mm, n-butanol-14 mm at 0.625 mg/mL). <em>E. coli</em> was inhibited by n-butanol fraction (13 mm at 2.5 mg/mL). Further, n-butanol fraction (400 µg/disc) exhibited promising activity against 14 bacteria, 2 dermatophytes and 2 yeasts strains.</p> ER -