TY - JOUR AU - Lee, Wei Cai AU - Mahmud, Roziahanim AU - Noordin, Rahmah AU - Piaru, Suthagar Pillai AU - Perumal, Shanmugapriya AU - Ismail, Sabariah PY - 2012/11/22 Y2 - 2024/03/28 TI - Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 7 IS - 4 SE - Research Articles DO - 10.3329/bjp.v7i4.12499 UR - https://www.banglajol.info/index.php/BJP/article/view/12499 SP - 272-276 AB - <p>The alkaloids content, cytotoxicity activity and anti-parasitic activity of <em>Tinospora crispa</em> Miers and Psidium guajava L. against parasite <em>Toxoplasma gondii</em> were investigated. Both of the crude plant extracts contained high amount of crude alkaloids and were not toxic to Vero cells (EC<sub>50</sub> &gt;100 µg/mL). Following non-toxicity finding of the extracts, the in vitro anti-parasitic assay was carried out with clindamycin served as the positive control. <em>T. crispa</em> stem crude extract with EC<sub>50</sub> value of 7.71 ± 1.56 µg/mL, showed potential anti-<em>T. gondii </em>activity as the results were comparable to clindamycin (EC<sub>50</sub> = 6.24 ± 0.53 µg/mL). These findings suggest that stem extract of<em> T. crispa</em> Miers contained some potential active compounds against <em>Toxoplasma gondii</em>. Selective important alkaloids in the <em>T. crispa</em> stem fractions may be the key factor for their anti-parasitic activity. Further study is being carried out to investigate for potential bioactives present in the <em>T. crispa</em> extract through bioactivity guided fractionation.</p> ER -