TY - JOUR AU - Gurudeeban, Selvaraj AU - Satyavani, Kaliyamurthi AU - Ramanathan, Thirugnanasambandam PY - 2012/09/23 Y2 - 2024/03/28 TI - Alpha-glucosidase inhibitory effect and enzyme kinetics of coastal medicinal plants JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 7 IS - 3 SE - Research Articles DO - 10.3329/bjp.v7i3.11499 UR - https://www.banglajol.info/index.php/BJP/article/view/11499 SP - 186-191 AB - <p>Numerous metabolic disorders and diseases associated with the glucosidase enzyme activity. Therefore, in the present study we evaluated alpha glucosidase inhibitory effect of coastal medicinal plants on Saccharomyces cerevisiae alpha-glucosidase to control postprandial hyperglycemia. The n-hexane extracts of study plants screened for alpha-glucosidase inhibitory activity using yeast glucosidase. The enzyme kinetics studied Line weaver burk plot method. Among the ten plants <em>Citrullus colocynthis, Aegle marmelos</em> and <em>Ipomoea pescaprae</em> exhibited potent alpha-glucosidase inhibitory activity, 85.9 ±0.10, 72.23 ± 0.30 and 67.9 ± 0.11 respectively. From the enzyme kinetics assay potent plants contain uncompetitive inhibitors of alpha glucosidase. <em>C. colocynthis, A. marmelos</em> and<em> Ipomoea pescaprae</em> have potential alpha-glucosidase inhibitors that can exploited for its used to treat diabetes.</p> ER -