TY - JOUR AU - Rasul, Azhar AU - Parveen, Saima AU - Ma, Tonghui PY - 2012/03/11 Y2 - 2024/03/28 TI - Costunolide: A novel anti-cancer sesquiterpene lactone JF - Bangladesh Journal of Pharmacology JA - Bangladesh J Pharmacol VL - 7 IS - 1 SE - Mini Review DO - 10.3329/bjp.v7i1.10066 UR - https://www.banglajol.info/index.php/BJP/article/view/10066 SP - 6-13 AB - <p>Currently an ample interest is found among oncologists to explore anticancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plant-derived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anticancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor cell lines. This review is aimed to summarize the recent researches about costunolide focusing on anti-tumor activity and to lay emphasis on its molecular targets and its mechanisms, which may help the further design and conduct of preclinical and clinical trials.</p> ER -