@article{Shah_Begum_Hassan_Ali_Siddiqui_Gilani_2011, title={Pharmacological basis for the medicinal use of Psidium guajava leave in hyperactive gut disorders}, volume={6}, url={https://www.banglajol.info/index.php/BJP/article/view/8692}, DOI={10.3329/bjp.v6i2.8692}, abstractNote={<p><em>Psidium guajava</em> L. is reputed for its medicinal use in hyperactive gut disorders. This study was aimed to investigate mechanism responsible for its medicinal use in diarrhea and gut spasm. In castor oil-induced diarrheal model, the crude extract of<em> P. guajava</em> (100-1,000 mg/kg), provided 20.52-81.05% protection, similar to loperamide. In isolated rabbit jejunum preparations, crude extract was found more potent against high K<sup>+ </sup>than spontaneous pre-contractions, similar to verapamil, with EC<sub>50 </sub>values of 0.66 (0.44-0.97; n=8) and 2.28 mg/mL (1.43-3.62; n=8), respectively, suggests calcium channel blocking activity, as a possible mode of action. The Ca<sup>++</sup> channel blocking activity was further confirmed when pre-treatment of tissue with crude extract (0.3-1 mg/mL) caused a rightward shift in the Ca<sup>++</sup> concentration-response curves, similar to verapamil. Loperamide also inhibited spontaneous and high K<sup>+</sup>-induced contractions and shifted the Ca<sup>++</sup> curves to the right. These data indicate that crude extract of <em>P. guajava</em> possesses Ca<sup>++</sup> antagonist-like constituent(s), which explain its inhibitory effect on gut motility.</p>}, number={2}, journal={Bangladesh Journal of Pharmacology}, author={Shah, Abdul Jabbar and Begum, Sabira and Hassan, Syed Imran and Ali, Syed Nawazish and Siddiqui, Bina Shaheen and Gilani, Anwarul-Hassan}, year={2011}, month={Dec.}, pages={100–105} }