@article{Bekhouche_Ozen_Boussaha_Koldas_Yenigun_Lassed_Demirtas_Benayache_Benayache_Zama_2018, title={Antioxidant, DNA-damage protection and anti-cancer properties of n-butanol extract of the endemic Perralderia coronopifolia}, volume={13}, url={https://www.banglajol.info/index.php/BJP/article/view/34255}, DOI={10.3329/bjp.v13i1.34255}, abstractNote={<p class="Abstract">This study was designed to evaluate in vitro the total phenolic, flavonoid content, antioxidant activity, oxidative DNA-damage protection and anti-cancer activity of n-butanol extract from Perralderia coronopifolia, endemic plant. DNA protection capacity was performed using 46966 plasmid DNA against UV-photolysis of H<sub>2</sub>O<sub>2</sub>-induced oxidative damage. The antiproliferative effects of extract were performed on HeLa and C6 cells. Experimental results showed that extract had convenient number of phenolic and flavonoids. Furthermore, it provided strong anti-oxidant, reducing power, hydrogen peroxide and higher DPPH· scavenging ability with IC<sub>50</sub>= 7.02 ± 0.02 µg/mL. As it shown an oxidative plasmid DNA-damage inhibition against UV-photolysis of H<sub>2</sub>O<sub>2</sub>, an anti-cancer activity athigher concentrations in cells. The data obtained that P. coronopifolia extract could be useful in human protection against infection and degenerative illness.</p> <p class="Abstract"><strong>Video Component of Methodology</strong>:</p> <p class="Abstract">Metal chelating activity:   2 min 56 sec   <a href="https://www.youtube.com/watch?v=OIZAALaMvt0">Click to watch</a></p>}, number={1}, journal={Bangladesh Journal of Pharmacology}, author={Bekhouche, Khadidja and Ozen, Tevfik and Boussaha, Sara and Koldas, Serkan and Yenigun, Semiha and Lassed, Somia and Demirtas, Ibrahim and Benayache, Fadila and Benayache, Samir and Zama, Djamila}, year={2018}, month={Mar.}, pages={82–89} }