@article{Saqib_Hassan_Imran_Aleem_Janbaz_2018, title={Pharmacological effects of Cnicus arvensis on the gastrointestinal system}, volume={13}, url={https://www.banglajol.info/index.php/BJP/article/view/32905}, DOI={10.3329/bjp.v13i1.32905}, abstractNote={<p class="Abstract">The current study was conducted to screen the possible pharmacological activity of Cnicus arvensis on the gastrointestinal system. The methanolic extract exerted concentration-dependent (0.01–3.0 mg/mL) spasmolytic effect using isolated tissue preparations of rabbit jejunum and caused relaxation of K<sup>+</sup>(80 mM)-induced spastic contractions. There was non-parallel shift in Ca<sup>++ </sup>concentration response curves towards right at tissue bath concentrations of 0.3 and 1.0 mg/mL. The solvent-solvents fractionation revealed domination of spasmolytic effects in petroleum ether fraction as compared to aqueous fraction. The methanolic extract also found to reduce the retching in chicks at 150 mg/kg as compared to chlorpromazine. The methanolic crude extract also found to reduce the number of wet spots using castor oil-induced diarrhea in rat as compare to loperamide. Our results reflected the presence of Ca<sup>++</sup> channel blocking activity in methanolic extract, thus rationalizing the medicinal use of C. arvensis in diarrhea and vomiting.</p>}, number={1}, journal={Bangladesh Journal of Pharmacology}, author={Saqib, Fatima and Hassan, Sakeena and Imran, Imran and Aleem, Ambreen and Janbaz, Khalid Hussain}, year={2018}, month={Jan.}, pages={16–22} }