@article{Merugumolu_Chandrashekara_2016, title={Synthesis and anti-depressant evaluation of novel pyrazolone derivatives}, volume={11}, url={https://www.banglajol.info/index.php/BJP/article/view/25859}, DOI={10.3329/bjp.v11i2.25859}, abstractNote={<p class="Abstract">Diazotization of substituted anilines with NaNO<sub>2</sub> and concentrated hydrochloric acid at 0ºC gave the diazonium chlorides. Coupling of substituted aryl diazonium chlorides with ethyl acetoacetate in methanol gave ethyl-2-aryl-hydrazono-3-oxobutyrates (2a-h). Reaction of (2a-h) with naphthoic carbohydrazide (3) gave the title compounds pyrazolone derivatives (4a-h). The newly synthesized compounds were screened for their <em>in vivo</em> anti-depressant activity by tail suspension test and forced swimming test. Some of the tested compounds 4f, 4g showed very good activity when compared to the standard drug imipramine. The newly synthesized compounds were characterized by physical parameters and the structures were elucidated by spectral data.</p><p><strong>Video Clips of Methodology:</strong></p><p>Forced swimming test: 12 min 19 sec   <a href="https://www.youtube.com/v/TZtb2a5u4CU">Full Screen</a>   <a href="https://www.youtube.com/watch?v=TZtb2a5u4CU">Alternate</a></p><p>Tail suspension test: 8 min 5 sec   <a href="https://www.youtube.com/v/92mFRfBJgBw">Full Screen</a>   <a href="https://www.youtube.com/watch?v=92mFRfBJgBw">Alternate</a></p>}, number={2}, journal={Bangladesh Journal of Pharmacology}, author={Merugumolu, Vijay Kumar and Chandrashekara, Revanasiddappa Bistuvalli}, year={2016}, month={May}, pages={558–563} }