@article{Li_Xu_Bao_Li_Qu_2015, title={Protective effects of paeonol on cardiovascular complications in diabetes mellitus involves modulation of PI3K /Akt-GSK-3β signalling, regulation of protease-activated receptor-1 expressions and down-regulation of inflammatory mediators}, volume={10}, url={https://www.banglajol.info/index.php/BJP/article/view/24334}, DOI={10.3329/bjp.v10i4.24334}, abstractNote={<p class="Abstract">The present study was taken as an effort to assess the effects of paeonol on diabetic cardiomyopathy. Diabetes was induced in separate groups of Sprague-Dawley rats using streptozotocin. Treatment group animals received paeonol (50, 100 or 200 mg/kg body weight/day; orally) 5 weeks after streptozotocin induction for 6 weeks. Paeonol strikingly reduced myocardial apoptosis and improved cardiac function and myocardial architecture. Serum levels of glucose, reactive oxygen species and inflammatory mediators (TNF-α, IL-6 and IL-1β) were significantly reduced with decreased accumulation of collagen in the cardiac tissue. Paeonol modulated p-Akt, glycogen synthase kinase-3β and glycogen synthase, while significantly down-regulated protease-activated receptor-1, caspase-3, TNF-α, NF-κB p65, and p-Iκ-Bα expressions. Paeonol effectively suppressed diabetic cardiomyopathy by improving myocardial function, regulating the inflammatory responses and Akt signalling.</p>}, number={4}, journal={Bangladesh Journal of Pharmacology}, author={Li, Jun and Xu, Ze-Qing and Bao, Ling and Li, Zhi-Cao and Qu, Jia-Xiang}, year={2015}, month={Nov.}, pages={903–916} }