@article{Nayab_Pulaganti_Chitta_Oves_._2015, title={Synthesis, spectroscopic studies of novel N-substituted phthalimides and evaluation of their antibacterial, antioxidant, DNA binding and molecular docking studies}, volume={10}, url={https://www.banglajol.info/index.php/BJP/article/view/23637}, DOI={10.3329/bjp.v10i3.23637}, abstractNote={<p class="Abstract">A new series of N-substituted phthalimide derivatives were prepared by condensation of appropriate amount of n-amino tetrachlorophthalimide with respective aldehyde in glacial acetic acid. The structural investigation of the synthesized compounds was done by spectroscopic methods (UV-Vis., IR, <sup>1</sup>H and <sup>13</sup>C NMR) and elemental analysis. The antibacterial screening of these compounds was performed against Escherichia coli and Staphylococcus mutans. The synthesized compounds were evaluated for their antioxidant potential using 2,2-diphenyl-1-picrylhydrazyl (DPPH) as a scavenging agent. The interaction ability of most promising compounds (3a and 3b) with native calf thymus DNA (Ct-DNA) was also studied by means of UV-Vis., circular dichroism (CD), viscosity measurements and thermal studies. The intrinsic binding constants (K<sub>b</sub>) of 3a and 3b with Ct-DNA obtained from UV-Vis. absorption studies were 8 × 10<sup>4</sup> and 1 × 10<sup>5</sup>, respectively. Molecular docking of target compounds (3a and 3b) against DNA dodecamer d(CGCGAATTCGCG)<sub>2</sub> has been carried out. The test compounds exhibited remarkable antibacterial, antioxidant and DNA binding activities.</p> <p> </p>}, number={3}, journal={Bangladesh Journal of Pharmacology}, author={Nayab, Pattan Sirajuddin and Pulaganti, Madhusudana and Chitta, Suresh Kumar and Oves, Mohammad and ., Rahisuddin}, year={2015}, month={Aug.}, pages={703–713} }