@article{Fan_Han_Zhang_Xi_2015, title={Studies of in vitro anti-prostate cancer potential of newer 1,2,4-triazolo-1,3,4-thiadiazines with different heteroaromatics}, volume={10}, url={https://www.banglajol.info/index.php/BJP/article/view/22424}, DOI={10.3329/bjp.v10i2.22424}, abstractNote={<p>This study was aimed to evaluate anticancer potential of newer synthesize 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines and its derivatives. All newly furnished scaffolds were subjected to screening for their in vitro anticancer potential against DU-145 and PC-3 prostate cancer cell lines using SRB and MMT bioassays. The structures of final compounds were confirmed with the aid of FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR spectroscopy and CHN analysis. Bioassay studies suggested that all thiadiazines were promising cytotoxic agents with % cytotoxicity ranging from 44.39-71.24%, whereas potent GI<sub>50</sub> level in the range 11.96-32.51 µg/mL and results were comparable to the potencies of control drugs adriamycin and doxorubicin. Variation of heterocyclic pharmacophores along with the C-5 position of 1,2,4-triazole in terms of quinoline, quinazoline, coumarin and pyridine lead to the different SAR predictions in which quinoline and benzimidazole moieties found most promising.</p>}, number={2}, journal={Bangladesh Journal of Pharmacology}, author={Fan, Mao-Chuan and Han, Guang-Ye and Zhang, Xin-Jun and Xi, Hui-Fang}, year={2015}, month={Apr.}, pages={308–315} }