@article{Bajpai_Kang_2014, title={Antimycotic potential of a diterpenoid taxoquinone against Candida species isolated from Metasequoia glyptostroboides}, volume={9}, url={https://www.banglajol.info/index.php/BJP/article/view/17555}, DOI={10.3329/bjp.v9i2.17555}, abstractNote={<p>The objective of this study was to confirm the antimycotic potential of a diterpenoid compound taxoquinone, isolated from <em>Metasequoia glyptostroboides</em> against pathogenic isolates of <em>Candida</em> species. The taxoquinone (100 mcg/disc) displayed potential anticandidal effect against <em>Candia albicans </em>KBN06P00076, KBN06P00074, C. glabrata KBN06P00066, KBN06P00068, C. tropicalis KBN06P00682, KBN06P00058, C. parapsilosis KBN06P00060, KBN06P00055, and <em>C. guilliermondii</em> KBN06P00492 and KBN06P00867 as a diameter of zones of inhibition, found in the range of 10 ± 0.6 to 13 ± 1.1 mm. The minimum inhibitory and minimum fungicidal concentrations of taxoquinone against the tested clinical isolates were found in the range of 125 to 500 and 125 to 1,000 mcg/mL, respectively. On the viable counts of the tested fungal isolates, the taxoquinone evoked a remarkable anticandidal effect. Elaborative study of SEM revealed potential detrimental effect of taxoquinone on the morphology of <em>C. parapsilosis</em> KBN06P00060 at MIC concentration. These findings confirmed therapeutic potential of taxoquinone.</p>}, number={2}, journal={Bangladesh Journal of Pharmacology}, author={Bajpai, Vivek K. and Kang, Sun Chul}, year={2014}, month={Mar.}, pages={154–160} }