@article{Sun_Shui_Li_Yang_Liu_Zhang_2012, title={In vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose from Radix isatidis on infuenza virus A}, volume={7}, url={https://www.banglajol.info/index.php/BJP/article/view/11228}, DOI={10.3329/bjp.v7i3.11228}, abstractNote={<p>To investigate the <em>in vitro</em> anti-viral effect of fructopyrano-(1→4)-glucopyranose (FG) from traditional Chinese medicine Radix isatidis, dog kidney cells (MDCK) were with treated with either FG and then with virus (Group A); virus and then with FG (Group B); or FG and virus simultaneously (Group C). Results showed the <em>in vitro</em> cell protection rate and virus inhibition rate increased significantly with the increase of FG concentration when compared with cells without FG treatment (p<0.01). The anti-viral effect was the best in Group C and that in Group A was superior to that in Group B. FG could exert significant inhibited effect on neuraminidase activity with the IC<sub>50</sub> of 0.07 mmol/mL and on hemagglutinin of avian influenza virus with minimum inhibitory concentration of 3.13 mg/mL. Our findings indicate FG can confer obvious antiviral effects on influenza A virus <em>in vitro</em>.</p>}, number={3}, journal={Bangladesh Journal of Pharmacology}, author={Sun, Qin and Shui, Pi-Xian and Li, Han-Bin and Yang, Si-Jin and Liu, Ming-Hua and Zhang, Shi-Jing}, year={2012}, month={Jul.}, pages={145–149} }