Cardiovascular inhibitory properties of Lens culinaris

Authors

  • Munasib Khan Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College, Karachi-74800, Pakistan Department of Pharmacy, University of Malakand, Chakdara, Dir (L), Pakistan
  • Arif-ullah Khan Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad
  • Najeeb-ur Rehman Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle
  • Anwarul-Hassan Gilani Natural Products Research Unit, Department of Biological and Biomedical, Sciences, Aga Khan University Medical College, Karachi

DOI:

https://doi.org/10.3329/bjp.v9i3.19090

Keywords:

Lens culinaris, hypotensive, vasodilator, cardio-depressant

Abstract

In present study, we report the blood pressure lowering, vasodilatory and cardio-depressant activities of Lens culinaris. The crude extract of L. culinaris induced dose-dependent (3-30 mg/kg) fall in the arterial pressure of rats under anesthesia. When tested in rat aortic ring preparations, L. culinaris at concentration range of 0.03-5.0 mg/mL relaxed high K+ (80 mM) and phenylephrine (1 ?M)-induced contractions, like that caused by verapamil. In isolated guinea-pig atria, L. culinaris caused inhibition of atrial force and rate of spontaneous contractions, similar to that exhibited by verapamil. These data indicate that L. culinaris exhibits blood pressure lowering potential, mediated possibly through Ca++ channel blockade mechanism.

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Published

2014-07-22

How to Cite

Khan, M., A.- ullah Khan, N.- ur Rehman, and A.-H. Gilani. “Cardiovascular Inhibitory Properties of Lens Culinaris”. Bangladesh Journal of Pharmacology, vol. 9, no. 3, July 2014, pp. 303-6, doi:10.3329/bjp.v9i3.19090.

Issue

Vol. 9 No. 3 (2014)

Section

Research Articles

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