Hepatoprotective effects of methanolic extract of Alcea rosea against acetaminophen-induced hepatotoxicity in mice

  • Liaqat Hussain Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad
  • Muhammad Sajid Hamid Akash Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058
  • Madeha Tahir Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad
  • Kanwal Rehman Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou
  • Khwaja Zafar Ahmed Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad
Keywords: Acetaminophen, Alcea rosea, Bilirubin, Hepatotoxicity, Liver enzyme marker

Abstract

The aim of this study was to evaluate the hepatoprotective effects of Alcea rosea against acetaminophen-induced hepatotoxicity in mice. Aqueous methanolic extract of A. rosea were given orally for 7 consecutive days followed by daily toxic dose of acetaminophen. At the end of treatment period, evaluation of hepatoprotective activity of A. rosea was done on basis of levels of liver enzyme markers (aminotransferases, alkaline phosphatase and bilirubin) and histopathological examination of liver tissues. Acetaminophen significantly increased serum levels of liver enzyme markers whereas, the extract of A. rosea significantly reduced serum levels of elevated liver enzyme markers in dose-dependent manner compared to acetaminophen treated mice group. Histopathological examination of liver tissues also supported the protective effects of A. rosea on liver enzyme markers. We conclude that extract of A. rosea has strong hepatoprotective effects against acetaminophen-induced hepatotoxicity; thereby, affirming its traditional therapeutic role in liver injury.

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Published
2014-07-31
How to Cite
Hussain, L., M. S. Akash, M. Tahir, K. Rehman, and K. Ahmed. “Hepatoprotective Effects of Methanolic Extract of Alcea Rosea Against Acetaminophen-Induced Hepatotoxicity in Mice”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, July 2014, pp. 322-7, doi:10.3329/bjp.v9i3.19068.
Section
Research Articles