Evaluation of antioxidant and hepatoprotective effects of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA)

Authors

  • Muhammad Shoaib Akhtar Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100
  • Hafiz Muhammad Mazher Asjad Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100
  • Sajid Bashir Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha40100
  • Abdul Malik Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100
  • Rehan Khalid Department of Physiology and Pharmacology, Faculty of Veterinary Sciences, University of Agriculture, Faisalabad 40100
  • Faisal Gulzar Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100
  • Nadeem Irshad Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100

DOI:

https://doi.org/10.3329/bjp.v8i1.13183

Keywords:

Antioxidant, Ascorbic acid, Carbon tetrachloride toxicity, Hepatoprotective, Polyherbal formulation

Abstract

Despite widespread use of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA) in the traditional medicine, there was a lack of scientific evidence on its efficacy and safety. The present investigation was designed to evaluate its ex vivo antioxidant and in vivo hepatoprotective properties against carbon tetrachloride toxicity in albino rats. At first phytochemicals analysis of test preparation was conducted to estimate its total phenolic and flavonoid contents. Then their antioxidant activity was determined by various tests and compared it with standards ascorbic acid and rutin. Afterwards, hepatoprotective activity was studied against carbon tetrachloride-induced liver damage by determining SGOT, SGPT, ALP, total cholesterol, bilirubin and total proteins contents in the serum of rats before and after treatment. This suggests that the hepatoprotective activity of formulation is possibly attributed to its free radical scavenging properties.

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Author Biographies

Muhammad Shoaib Akhtar, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100

Professor

Hafiz Muhammad Mazher Asjad, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100

Research Scholar

Sajid Bashir, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha40100

Chairman

Abdul Malik, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100

Lecturer

Rehan Khalid, Department of Physiology and Pharmacology, Faculty of Veterinary Sciences, University of Agriculture, Faisalabad 40100

Scholar

Faisal Gulzar, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100

Scholar

Nadeem Irshad, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100

Research Scholar

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Additional Files

Published

2013-01-13

How to Cite

Akhtar, M. S., H. M. Mazher Asjad, S. Bashir, A. Malik, R. Khalid, F. Gulzar, and N. Irshad. “Evaluation of Antioxidant and Hepatoprotective Effects of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA)”. Bangladesh Journal of Pharmacology, vol. 8, no. 1, Jan. 2013, pp. 44-48, doi:10.3329/bjp.v8i1.13183.

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Section

Research Articles