Anti-cancer drug from red tomato skin

Bangladesh Journal of Pharmacology News | Feature | 15 July 2016

Summary: In vivo results showed that both tumor volume and tumor weight were lesser in naringenin chalcone-treated groups with its different doses of naringenin chalcone than in control group

Source: Qilu Hospital, Shandong University

Red tomato skin contains flavonoids. It also contains naringenin chalcone, an intermediate in the biosynthesis of flavonoids. Some chalcones have been shown to have antibacterial and antifungal activities. Naringenin chalcone has anti-allergic activity. The anti-cancer effect of naringenin chalcone has been reported which is mediated via the induction of autophagy, apoptosis and activation of PI3K/Akt signalling pathway.

Chinese scholars lead by Dr. Wen-Hua Zhang published their findings in the recent issue of Bangladesh Journal of Pharmacology.

Photograph: Autophagy-induction by naringenin chalcone in U87MG human glioblastoma cells