Apoptotic activity of quinine

Bangladesh Journal of Pharmacology News | Feature | 9 June 2016

Summary: Quinine treatment significantly inhibited the cancer cell viability, colony formation, leading to increased reactive oxygen species generation, induction of mitochondrial membrane potential depolarization, morphological changes and deoxyribonucleic acid damage in a dose and time-dependent manner.

Source: Annamalai University

Indian scientist Dr. K. Suresh and his team conducted an study using laryngeal and mouth epidermoid carcinoma cells to examine the antiproliferative and apoptotic effect of quinine. They suggest that quinine might be a potential candidate to prevent cell proliferation, and enhanced apoptosis via inhibiting nuclear factor kappa B signaling pathway in the carcinoma cell lines studied. Their data are recently published in Bangladesh Journal of Pharmacology.

In conclusion, they propose that quinine forms a potential preventive candidate for inflammatory and apoptotic related disorders of any type as it is a natural products from medicinal plants.

Photograph showing the apoptotic activity of quinine in cancer cells