Bryostatin I inhibits synuclein-A expression

Bangladesh Journal of Pharmacology News | Feature | 14 June 2016

Summary: Bryostatin I inhibits the growth of breast cancer cells through the inhibition of synuclein-A expression.

Source: The Second People’s Hospital of Huaian

The macrolid lactone bryostatin I was first obtained from Bugula neritina collected from the local marina on the northern Florida coast of the Gulf of Mexico in 1968. Subsequently it was found that bryostatin I modulates the enzyme protein kinase C and can be used in the treatment of cancer. Recently Chinese scientists published a paper in Bangladesh Journal of Pharmacology showing that the inhibitory of bryostatin I on the grwoth of breast cancer cell is mediated by inhibition of synuclein-A expression.

Photograph: Bugula neritina