TY - JOUR AU - Mukherjee, Sudipta Kumer AU - Arman, DM AU - Roy, Holly A AU - Khan, Rafiul Karim AU - Afreen, Samantha AU - Hossain, Muhammad Arif AU - Md Ziauddin, - AU - Ekramullah, Sk Md AU - Rahman, Md Moshiur AU - Yusuf, Md Abdullah AU - Islam, Md Joynul PY - 2020/01/14 Y2 - 2024/03/29 TI - Status of ToRCH positivity among the children presented with congenital Hydrocephalus JF - Bangladesh Journal of Neurosurgery JA - Bangla J. Neurosurgery VL - 9 IS - 2 SE - Original Articles DO - 10.3329/bjns.v9i2.44886 UR - https://www.banglajol.info/index.php/BJNS/article/view/44886 SP - 121-125 AB - <p><strong>Introduction</strong>: ToRCH is an acronym for four congenital infections that are sometimes difficult to distinguish: <strong>To</strong>xoplasmosis, <strong>R</strong>ubella, <strong>C</strong>ytomegalovirus (CMV), and <strong>H</strong>erpes Simplex Virus (HSV). This group of organisms produces serious Central Nervous System (CNS) and other infections, which are potentially preventable and treatable.</p><p><strong>Methods</strong>: Neonates and infants with hydrocephalus (N = 65) identified via the outpatient department of the National Institute of Neurosciences and Hospital (NINS&amp;H), were prospectively screened for ToRCH antibodies. Hydrocephalus secondary to Tumor or Trauma was excluded from this study.</p><p><strong>Results</strong>: Evidence of 75.38 % (p = &lt;0.05) patient was positive for TORCH antibodies. Toxoplasma Gondi (T. Gondii) IgG 18.5 % ( p= &lt;0.05 ), CMV IgM 9.2 % (p = &lt;0.05), CMV Ig G47.7% ( p = &lt;0.5), Rubella, and HSV 1 &amp; 2 antibodies were also identified.</p><p><strong>Conclusion</strong>: The vast majority of cases of neonatal hydrocephalus at one institution was post-infectious in etiology and related to ToRCH infections. Many of these cases could be prevented with improved screening and treatment. While study of a single institution may not be the representative of the entire population, further study and implementation of a standardized screening protocol would likely benefit this population.</p><p>Bang. J Neurosurgery 2020; 9(2): 121-125</p> ER -