18F PSMA-1007 and 18F FDG PET/CT in an Advanced Prostate Cancer Patient - A Case Report

Authors

  • Pupree Mutsuddy Associate Professor and Principal Medical Officer. NINMAS, Block-D, BSMMU Campus, Shahbag, Dhaka
  • Tapati Mandal Assistant Professor and Senior Medical Officer, NINMAS, Dhaka
  • Papia Akhter Assistant Professor and Senior Medical Officer, NINMAS, Dhaka
  • S M Arifur Rahman Medical Officer, NINMAS, Dhaka
  • Md Abu Bakker Siddique Professor and Chief Medical Officer, NINMAS, Dhaka
  • Fatima Begum Professor and Ex Director, NINMAS, Dhaka
  • Fatema Tuz Zohra Assistant Professor and Senior Medical Officer, Institute of Nuclear Medical Physics, Savar
  • Mohammad Anwar Ul Azim Associte Professor and Principal Scientific Officer, Planning Division, Bangladesh Atomic Energy Commission, Dhaka
  • Shamim MF Begum Professor and Ex Member, Planning Division, Bangladesh Atomic Energy Commission, Dhaka

DOI:

https://doi.org/10.3329/bjnm.v28i1.79558

Keywords:

Advanced Prostate cancer, 18F FDG (Fluorodeoxyglucose), 18F PSMA (Prostate Specific Membrane Antigen)-1007.

Abstract

Positron Emission Tomography (PET) is currently playing a crucial role in the assessment of prostate cancer. 68Ga/18F prostate-specific membrane antigen (PSMA), 11C Choline, and 18F Fluciclovine are the most commonly used non-FDG PET tracers. F-18 FDG PET is not routinely recommended in prostate cancer due to the low glycolytic nature of the prostate tumor cells. However, in advanced and aggressive cases, 18F FDG PET can detect lesions. Till September 2023, 18F-FDG was the only available PET tracer in our country to detect recurrence and non-osseous metastases. We reported a case of a 53-year-old male who underwent an 18F PSMA-1007 PET-CT scan for restaging in October 2023. The patient had a previous 18F FDG PET-CT scan in January 2023. FDG PET showed hypermetabolic cervical, mediastinal, and abdominal lymph nodes as well as multiple skeletal lesions. Patient received chemotherapy and anti-androgen therapy. However, after 10 months, patients PSA raised from 225 ng/ml to 616.5 ng/ml. In the PSMA scan, we found extensive nodal and skeletal involvements with progression of disease. In this case, an FDG-positive scan reflects the aggressiveness of the disease; however, extensive PSMA-avid lesions, including the positive lesions in FDG, indicate the patient could benefit from PSMA-based therapy.

Bangladesh J. Nuclear Med. 28(1): 174-177, 2025

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Published

2025-04-13

How to Cite

Mutsuddy, P., Mandal, T., Akhter, P., Rahman, S. M. A., Siddique, M. A. B., Begum, F., … Begum, S. M. (2025). 18F PSMA-1007 and 18F FDG PET/CT in an Advanced Prostate Cancer Patient - A Case Report. Bangladesh Journal of Nuclear Medicine, 28(1), 174–177. https://doi.org/10.3329/bjnm.v28i1.79558

Issue

Section

Case Reports