Current Status of Newborn Screening for the early Diagnosis of Congenital Hypothyroidism in Bangladesh

Authors

  • Mohammad Anwar Ul Azim National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Md Ariful Islam National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Sanchoy Chandra Biswasarma National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Md Jashim Uddin National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Zeenat Jabin National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Fatima Begum National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Shamim MF Begum National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Bangladesh Atomic Energy Commission (BAEC), BSMMU, Shahbag, Dhaka-1000
  • Faridul Alam Ex-Director, NINMAS, BAEC, BSMMU, Shahbag, Dhaka-1000
  • Mizanul Hasan Ex-Director, NINMAS, BAEC, BSMMU, Shahbag, Dhaka-1000
  • Nurun Nahar Ex-Director, NINMAS, BAEC, BSMMU, Shahbag, Dhaka-1000
  • Jasmine Ara Haque
  • Hosne Ara Rahman Mitford, Bio-Science, BAEC, Dhaka
  • Gazi Abul Hossain Mymensingh, Bio-Science, BAEC, Dhaka
  • Shakila Zaman Rima Mymensingh, Bio-Science, BAEC, Dhaka
  • Kamrun Nahar Sylhet, Bio-Science, BAEC, Dhaka
  • Murshed Ali Rangpur, Bio-Science, BAEC, Dhaka
  • Jharna Das Khulna, Bio-Science, BAEC, Dhaka
  • Nafisa Jahan Barishal, Bio-Science, BAEC, Dhaka
  • Mostofa Shamim Ahsan Rajshahi, Bio-Science, BAEC, Dhaka
  • Shankar Kumar Dey Faridpur, Bio-Science, BAEC, Dhaka
  • Md Reajul Islam Cumilla, Bio-Science, BAEC, Dhaka
  • Md Abdul Awal Bogura, Bio-Science, BAEC, Dhaka
  • Md Sayeedul Alam Cox’s Bazar, Bio-Science, BAEC, Dhaka
  • BK Bose Dinajpur, Bio-Science, BAEC, Dhaka
  • AHM Roquibul Hoque Chattogram, Bio-Science, BAEC, Dhaka
  • Ashoke Kumar Paul Member, Bio-Science, BAEC, Dhaka
  • Faria Nasreen Director, Bio sciences Division, BAEC, Dhaka, Bangladesh
  • Sanowar Hossain
  • Fauzia Moslem Ex-Director, Bio-Science Division, BAEC, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjnm.v25i1.59636

Keywords:

Newborn Screening, Congenital hypothyroidism, TSH, IRMA, DELFIA.

Abstract

Background: Newborn screening programs signify early and presymptomatic detection of treatable disorders which authorize commencement of prompt medication to alleviate notable fatality. Newborn screening (NBS) for congenital hypothyroidism (CH) has been a successful public health initiative in preventive medicine over the last few decades. Previous pilot (1999-2006) and phase 1 (2006-2011) NBS program in Bangladesh reported an increased incidence compared to global data which urged to initiate a second phase NBS program for the detection of CH.

Materials & Methods: Neonates’ blood was collected from the umbilical cord or by heel prick and drawn on the Guthrie filter paper card. Thyroid-stimulating hormone (TSH) was measured from this filter paper by Immunoradiometric assay (IRMA) or Dissociation Enhanced Lanthanide Fluorescence Immunoassay (DELFIA) method.

Results: 123 out of 2,61,550 neonates have already been diagnosed with congenital hypothyroidism from September 2018 to August 2020, which represents an incidence of 1:2126.

Conclusion: Ongoing phase-2 project data is already showing some optimistic outcomes. Hence, a time-worthy sustainable policy should be implemented to mark this program as an effective one.

Bangladesh J. Nuclear Med. 25(1): 15-21, 2022

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Published

2022-05-25

How to Cite

Ul Azim, M. A., Islam, M. A. ., Biswasarma, S. C., Uddin, M. J. ., Jabin, Z. ., Begum, F., … Moslem, F. (2022). Current Status of Newborn Screening for the early Diagnosis of Congenital Hypothyroidism in Bangladesh. Bangladesh Journal of Nuclear Medicine, 25(1), 15–21. https://doi.org/10.3329/bjnm.v25i1.59636

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