Young woman with Multiple Endocrine Neoplasia 2B (MEN 2B) Diagnosed by PET-CT-A Case Report

Authors

  • Rawnak Afrin
  • Shankar Biswas Institute of Nuclear medicine & Allied Sciences, Dhaka
  • Shaila Sharmin Institute of Nuclear medicine & Allied Sciences, Dhaka
  • ABM Golam Mostofa Department of Medicine, DMCH, Dhaka
  • Jasmine Ara Haque Institute of Nuclear medicine & Allied Sciences, Dhaka

DOI:

https://doi.org/10.3329/bjnm.v24i1-2.59338

Keywords:

MEN 2B, 18 F-FDG PET-CT

Abstract

Multiple endocrine neoplasia, type 2B (MEN2B) is an autosomal dominant syndrome characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas & intestinal ganglioneuromas. A young woman of 20 years presented with irregularity of both lips since childhood and a midline neck swelling which gradually increased in size within last 1 year. She had hypertension and history of three episodes of paroxysmal spells characterized by headache, palpitations and excessive sweating during past 5 months. On physical examination, patient was having tachycardia, high blood pressure level (140/100 mmHg), sweaty with no tremor or exophthalmos. She had bumpy lips, multiple mucosal neuromas in lip & buccal mucosae, a hard nodular goiter and no marfanoid habitus. Core biopsy from right thyroid lobe revealed medullary thyroid carcinoma. Calcitonin level were markedly elevated. 18F-FDG PET-CT scan showed heterogeneous mixed density soft tissue mass involving both lobes and isthmus of thyroid gland with intense FDG uptake and FDG avid enlarged right cervical lymph nodes. A well circumscribed complex mass was found in the left upper abdomen adjacent to pancreas. Left adrenal gland showed a heterogeneous mass with mild FDG uptake and according to PET-CT findings, patient was diagnosed as a case of MEN 2B.

Bangladesh J. Nuclear Med. 24(1&2): 60-63, 2021

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Published

2022-05-24

How to Cite

Afrin, R. ., Biswas, S. ., Sharmin, S. ., Mostofa, A. G. ., & Haque, J. A. . (2022). Young woman with Multiple Endocrine Neoplasia 2B (MEN 2B) Diagnosed by PET-CT-A Case Report. Bangladesh Journal of Nuclear Medicine, 24(1-2), 60–63. https://doi.org/10.3329/bjnm.v24i1-2.59338

Issue

Section

Case Reports