Installation of First Medium Energy Medical Cyclotron in Bangladesh at National Institute of Nuclear Medicine and Allied Sciences (NINMAS) for PET radiopharmaceuticals Production

Authors

  • Mohammad Anwar Ul Azim National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Sanchoy Chandra Biswasarma National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Jashim Uddin National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Md Ariful Islam National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Nahid Hossain National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Md Shohag Mia National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Hasan Mehdi National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Md Alamgir Kabir National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Mustafa Mamun
  • Ferdoushi Begum National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Shamim Momtaz Ferdousi Begum National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BAEC, BSMMU Campus, Shahbag, Dhaka-1000
  • Md Nurul Islam Physical Science Division, Bangladesh Atomic Energy Commission (BAEC), Agargaon Dhaka

DOI:

https://doi.org/10.3329/bjnm.v24i1-2.59335

Keywords:

Cyclotron, 18F-FDG, PET-CT.

Abstract

PET-CT (positron emission tomography and computed tomography) is a gold-standard cancer imaging tool for diagnosis and management, as well as prognostic information based on treatment. Positron-emitting radionuclide 18F (Fluorine) is generated by accelerating particles to energies high enough to cause a certain nuclear reaction 18O(p,n)18F within the particle accelerator, the cyclotron. Mannose triflate is converted to 2-[18F] Fluoro-2-deox-D-yglucose ([18F]FDG) via nucleophilic reaction. Under the ownership of Bangladesh Atomic Energy Commission installed a medium energy (18/9 MeV, IBA) Cyclotron at National Institute of Nuclear Medicine and Allied Sciences (NINMAS). The facility was established in the oncology Building (Block F) of Bangabandhu Sheikh Mujib Medical University (BSMMU). Cyclotron vault and the Control room are located in the underground i.e. basement floor. Each wall of the cyclotron vault and ceiling is made of concrete with a density of 2.35 g/cm3 and a thickness sufficient to shield gamma and neutron radiation. On the ground floor, there are Synthesis room, Quality control laboratory, and the Decontamination room. PET-CT rooms are located on the first floor. Identification, Radionuclide purity (Gamma spectrum detection and half-life measurement), Radiochemical Purity, Chemical purity, Residual solvent measurement, pH measurement, Sterility, and bacterial endotoxins (LAL test) are performed to maintain the quality of the product. The current uses of the Cyclotron are mostly for the synthesis of 18F-FDG.

Bangladesh J. Nuclear Med. 24(1&2): 48-50, 2021

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Published

2022-05-24

How to Cite

Ul Azim, M. A., Biswasarma, S. C. ., Uddin, J., Islam, M. A. ., Hossain, N. ., Mia, M. S., Mehdi, H., Kabir, M. A., Mamun, M., Begum, F., Ferdousi Begum, S. M. ., & Islam, M. N. . (2022). Installation of First Medium Energy Medical Cyclotron in Bangladesh at National Institute of Nuclear Medicine and Allied Sciences (NINMAS) for PET radiopharmaceuticals Production. Bangladesh Journal of Nuclear Medicine, 24(1-2), 48–50. https://doi.org/10.3329/bjnm.v24i1-2.59335

Issue

Section

Short Communication