Association of Serum Ferritin with Amyotrophic Lateral Sclerosis: A Case Control Study

Authors

  • Md Kabiruzzaman Kabiruzzaman Assistant Professor, National Institute of Neurosciences and Hospital, Dhaka
  • AKM Anwar Ullah Professor, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • MA Hannan Professor, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Md Rezaul Karim Khan Professor, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Md Rafiqul Islam Professor, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Abu Naser Rezvi Professor, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Bahadur Ali Miah Associate Professor, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Mohammad Shah Zahirul Hoque Chowdhury Associate Professor cum RP, National Institute of Neurosciences and Hospital, Dhaka
  • Nuruddin Moahmmad Eusuf Assistant Professor, Adin Medical College Hospital, Dhaka
  • Abu Jafor Md Salauddin Assistant Professor, Satkhira Medical College, Dhaka
  • Abdul Alim Assistant Professor, National Institute of Neurosciences and Hospital, Dhaka
  • Md Khairul Kabir Patwari Assistant Professor, National Institute of Neurosciences and Hospital, Dhaka
  • - Humayun Neurologist, CMH, Dhaka
  • Mohammad Sayeed Hasan Assistant Professor, National Institute of Neurosciences and Hospital, Dhaka.
  • Rashed Imam Zahid Medical Officer, National Institute of Neurosciences and Hospital, Dhaka
  • AKM Golam Kabir Assistant Professor, Dept. of Radiology, National Institute of Neurosciences and Hospital, Dhaka
  • Md Masud Rana Medical Officer, Dept. of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka

Keywords:

Serum ferritin serum iron and ALS.

Abstract

Background: Despite conflicting results from prospective studies, substantial evidence is accumulating suggesting that high Serum Ferritin was associated with Amyotrophic Lateral Sclerosis.

Objective: Our aim was to find out the association of serum ferritin with Amyotrophic Lateral Sclerosis.

Methods: This was a retrospective, case-control study done in the Neurology, Department of Bangabandhu Sheikh Mujib Medical University on 76 subjects with equal number of cases and controls with their age ranging from 15 to 70 years. Results: The analysis revealed that serum ferritin were significantly high in ALS patients 158.9 ± 16.6 and p= 0.004 as compared to control 104.8 ± 7.9. The proportion of patients below 40 years of age was a bit higher. Predominance in male 73.7% and female 26.3%, predominantly workers or housewife 65% followd by day labourers 26%. A large proportion of patients in both groups were non-smoker (73.7% in case and 78.9 in control group).

Conclusions: High Serum ferritin is an important risk factor for ALS. A strong positive correlation was also observed between high serum iron and ALS in our study.

Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 76-82

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Published

2015-12-30

How to Cite

Kabiruzzaman, M. K., Ullah, A. A. ., Hannan, M., Khan, M. R. K. ., Islam, M. R. ., Rezvi, A. N., Miah, B. A., Hoque Chowdhury, M. S. Z. ., Eusuf, N. M. ., Md Salauddin, A. J. ., Alim, A. ., Kabir Patwari, M. K. ., Humayun, .-., Hasan, M. S., Zahid, R. I. ., Kabir, A. G. ., & Rana, M. M. (2015). Association of Serum Ferritin with Amyotrophic Lateral Sclerosis: A Case Control Study. Bangladesh Journal of Neuroscience, 31(2), 76–82. Retrieved from https://www.banglajol.info/index.php/BJN/article/view/57385

Issue

Vol. 31 No. 2 (2015)

Section

Original Articles