TY - JOUR AU - Das, S AU - Bordoloi, P K AU - Saikia, P AU - Kanodia, L PY - 2012/08/31 Y2 - 2024/03/29 TI - The analgesic and acute anti-inflammatory effect of the ethanolic extract of the leaves of Paederia foetida (EEPF) on experimental animal models JF - Bangladesh Journal of Medical Science JA - Bangladesh J Med Sci VL - 11 IS - 3 SE - Original Articles DO - 10.3329/bjms.v11i3.11723 UR - https://www.banglajol.info/index.php/BJMS/article/view/11723 SP - 206-211 AB - <p><strong><em>Objective:</em></strong>To study the analgesic and acute anti-inflammatory effect of the ethanolic extract of the leaves of Paederia foetida (EEPF) on experimental animal models. <strong><em></em></strong></p><p><strong><em>Materials and Methods: </em></strong>Fresh leaves were collected, air-dried, powdered, and percolated in 95% ethanol. Acute toxicity test was done according to OECD guidelines. Healthy albino rats (150-200 gm) of either sex were taken and divided into five groups with six animals in each group for central analgesic activity by tail flick method. Peripheral analgesic activity by 1% glacial acetic acid induced writhing test by taking albino mice (20-30 gm) of either sex which were divided into three groups with six animals in each. EEPF was used in a dose of 500 mg/kg bodyweight subcutaneously for tail-flick method and orally for writhing test. In tail-flick method the basal reaction time was taken and a cut-off period of 10 sec was observed. Reaction time were recorded at predrug, 15, 30, 60, 90, 120, 150 and 180 minutes after administration of drug . The standard drug used for central analgesic activity was pethidine 5 mg/kg bw, naloxone 1mg/kg as antagonist and naloxone 1mg/kg bw with 500mg/kg bw of EEPF to study the central mechanism of action. The standard drug used for peripheral analgesic activity was aspirin 100mg/kg bw orally. A control group was maintained in all the models. For anti-inflammatory study, three groups of animals of either sex (n = 6), weighing 150-200g of the species Rattus norvegicus were taken for the study. Group A was taken as control (Normal salie, 10 mL/kg body weight), Group B as test group (EEPF 500 mg/kg body weight), and Group C as standard (Aspirin 100 mg/kg body weight). The animals were studied for acute inflammation by Carrageenan-induced rat paw edema. Statistical analysis  was done by one-way analysis of variance followed by multiple comparison tests.</p><p><strong><em>Results: </em></strong>EEPF significantly increased the reaction time in tail-flick method (p&lt;0.05) whereas the combination of naloxone and EEPF decreased the reaction time indicating that naloxone inhibits the analgesic effect of EEPF. In 1% glacial acetic acid induced writhing EEPF reduced writhing significantly In acute inflammation, there was significant inhibition of paw edema in Groups B, C in comparison with Group A (P &lt; 0.05). <strong><em></em></strong></p><p><strong><em>Conclusion:</em></strong>The ethanolic extract of Paederia foetida has significant analgesic and anti-inflammatory activity.</p> <p>DOI: <a href="http://dx.doi.org/10.3329/bjms.v11i3.11723">http://dx.doi.org/10.3329/bjms.v11i3.11723</a></p> <p>Bangladesh Journal of Medical Science Vol. 11 No. 03 July’12</p> ER -