@article{Maltsev_2020, title={Features of folate cycle disorders in children with ASD}, volume={19}, url={https://www.banglajol.info/index.php/BJMS/article/view/46634}, DOI={10.3329/bjms.v19i4.46634}, abstractNote={<p><strong>Aim: </strong>to show the effect of genetically determined folate cycle deficiency in children with autism spectrum disorders (ASD).</p> <p><strong>Participants: </strong>89 children (57 boys; 32 girls, Ukraine, 2-10 years old); participants were diagnosed with ASD. The control group consisted of 34 children with ASD.</p> <p><strong>Diagnostic methods:</strong>polymerase chain reaction (PCR), complex immunological research, diagnosis of infection, determination of biomarkers.</p> <p><strong>Results and discussion:</strong>Hyperhomocysteinemia was revealed in 87% of cases (p <0.05; Z <Z0.05).The indicated form of immunodeficiency was noted among 91% participants in the study, while only in 27% children of the control group had a similar immunological phenotype.The serum concentration of folic acid was increased in 64%, and reduced in 21% of cases. An increase of vitamin B12 also occurred in 64%, and vitamin B6 - only in 43% of cases.</p> <p>Bangladesh Journal of Medical Science Vol.19(4) 2020 p.737-742</p>}, number={4}, journal={Bangladesh Journal of Medical Science}, author={Maltsev, DmitryV}, year={2020}, month={Apr.}, pages={737–742} }