Evaluation of Typhidot (IgM) for Early Diagnosis of Typhoid Fever

Authors

  • Zohra Begum Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Md Akram Hossain Department of Microbiology, Mymensingh Medical College, Mymensingh
  • AKM Shamsuzzaman Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Md Monjurul Ahsan Department of Paediatrics, Mymensingh Medical College Hospital, Mymensingh
  • AKM Musa Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Md Chand Mahmud Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Asma Azad Sumona Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Salma Ahmed Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Nahida Akhter Jahan Department of Microbiology, Mymensingh Medical College, Mymensingh
  • Md Abdul Khaleque Department of Paediatrics, Mymensingh Medical College Hospital, Mymensingh

DOI:

https://doi.org/10.3329/bjmm.v3i1.2964

Keywords:

Typhoid fever, Salmonella typhi, Typhidot (IgM) test

Abstract

Typhoid fever still continues to be a major public health problem, particularly in many developing countries. A simple, reliable, affordable and rapid diagnostic test has been a long-felt need of the clinicians. We, therefore, prospectively evaluated the sensitivity and specificity of Typhidot (IgM), a serological test to identify IgM antibodies against Salmonella typhi. The study was carried out in the department of Microbiology, Mymensingh Medical College, Mymensingh between June, 2006 and July, 2007, on a total of 100 samples from clinically suspected patients to have typhoid fever. Blood culture as well as Typhidot test were performed for each of the cases. Out of 100 clinically diagnosed typhoid fever, 14 were blood culture positive for S. typhi and 73 were Typhidot (IgM) positive. Among 14 culture positive cases, 13 (92.85%) were Typhidot (IgM) positive. The test was also positive in 04 (20%) out of 20 febrile controls. None of the healthy controls was positive by Typhidot (IgM). The sensitivity, specificity, positive predictive value and negative predictive value of the test using blood culture as gold standard were 92.85%, 90.00%, 76.47% and 97.29% respectively for typhoid fever. Typhidot (IgM) test is rapid, easy to perform and reliable test for diagnosing typhoid fever, and useful for small, less equipped laboratories as well as for the laboratories with better facilities.

Key words: Typhoid fever, Salmonella typhi, Typhidot (IgM) test  

doi: 10.3329/bjmm.v3i1.2964

Bangladesh J Med Microbiol 2009; 03 (01): 10-13

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Author Biographies

Zohra Begum, Department of Microbiology, Mymensingh Medical College, Mymensingh

Currently, Department of Microbiology, Community Based Medical College, Mymensingh

AKM Shamsuzzaman, Department of Microbiology, Mymensingh Medical College, Mymensingh

Currently, Begum Khaleda Zia Medical College, Sher-E-Bangla Nagar, Dhaka

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Published

2009-07-28

How to Cite

Begum, Z., Hossain, M. A., Shamsuzzaman, A., Ahsan, M. M., Musa, A., Mahmud, M. C., Sumona, A. A., Ahmed, S., Jahan, N. A., & Khaleque, M. A. (2009). Evaluation of Typhidot (IgM) for Early Diagnosis of Typhoid Fever. Bangladesh Journal of Medical Microbiology, 3(1), 10–13. https://doi.org/10.3329/bjmm.v3i1.2964

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Original Articles