Association of NT-proBNP level with severity in Acute Ischemic Stroke Patients

Authors

  • Mahbubul Hakim Mishu Resident, Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka-1100, Bangladesh.
  • Aminur Rahman Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka-1100, Bangladesh.
  • Md Alamgir Hossain Assistant Registrar, Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka- 1100, Bangladesh.
  • Ajay Kumar Agarwalla Registrar, Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka-1100, Bangladesh.
  • Biplab Paul Assistant Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka-1100, Bangladesh.
  • Pallab Kanti Saha Assistant Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka-1100, Bangladesh.
  • Shahjada Mohammad Dastegir Khan Associate Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka- 1100, Bangladesh.
  • M Golam Sarwar Assistant Registrar, Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka- 1100, Bangladesh.
  • Md Tariqul Islam Assistant Professor, Department of Neurology, Sir Salimullah Medical College, Dhaka-1100, Bangladesh.
  • Nazmuzzaman Palash Medical Officer, Neurology Department, Bangladesh Medical University, Dhaka, Bangladesh.
  • Sanjeeda Sharmeen Medical Officer, Radiology Department, Sarkari Karmachari Hospital, Dhaka, Bangladesh.
  • Farhana Jannat Resident, Department of Internal Medicine, Bangladesh Medical University, Dhaka, Bangladesh.
  • Mohammad Shahidul Islam Bhuiyan Senior Consultant, Department of Medicine, Sir Salimullah Medical College, Mitford Hospital. Dhaka.

DOI:

https://doi.org/10.3329/bjm.v37i1.86648

Keywords:

Acute Ischemic Stroke, N-terminal pro-brain natriuretic peptide (NT-proBNP), National Institute of Health Stroke Scale (NIHSS).

Abstract

Background: This study was aimed to assess association of NT-proBNP levels with severity in acute ischemic stroke patients which may help in severity assessment of these patients. Methods: This casecontrol study was conducted in the Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh from November, 2023 to October, 2024.Total 100 subjects were enrolled in this study. Among this, 50 acute ischemic stroke patients with history within 3 days and confirmed by CT scan of head or MRI of brain were selected purposively from the Neurology Department of Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh. Another 50 age and gender matched subjects were selected from this place for comparison. Venous blood samples were collected from these patients and analyzed for estimation of plasma NT-proBNP. Results: This study found mean plasma NT-proBNP level was significantly higher (333.0±221.9pg/ml) in acute ischemic stroke patients (Case group) than control group (109.4±131.1pg/ml). A moderately strong positive correlation was observed between plasma NT-pro BNP level and NIHSS score at admission (r = 0.566; p <0.001). Conclusion: Plasma NT- Pro BNP level was significantly associated with acute ischemic stroke and correlated with severity. It reveals plasma NT- proBNP as an important marker for severity assessment of acute ischemic stroke.

Bangladesh J Medicine 2026; 37(1): 15-20

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Published

2026-01-19

How to Cite

Mishu, M. H., Rahman, A., Hossain, M. A., Agarwalla, A. K., Paul, B., Saha, P. K., … Bhuiyan, M. S. I. (2026). Association of NT-proBNP level with severity in Acute Ischemic Stroke Patients. Bangladesh Journal of Medicine, 37(1), 15–20. https://doi.org/10.3329/bjm.v37i1.86648

Issue

Vol. 37 No. 1 (2026)

Section

Original Articles