Vitamin D Deficiency Associated Hyperparathyroidism May Be Related With Impaired Glucose Tolerance Without Any Associations With Cardiovascular Risk Factors

Authors

  • Md Shahed Morshed Emergency Medical Officer, Kurmitola General Hospital, Dhaka, Bangladesh
  • Md Firoj hossain Assistant Professor, Department of Endocrinology, Mugda Medical College, Dhaka, Bangladesh
  • Md Habibul Ghani Junior Consultant (Medicine), Jinjira 20 Bed Hospital, Keraniganj, Dhaka, Bangladesh
  • Ibrahim Faisal Consultant (Endocrinology), Indira Gandhi Memorial Hospital, Kanbaa Aisa Rani Higun, Male, Republic of Maldives
  • Tahniyah Haq Assistant Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • Shahjada Selim Associate Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Md Fariduddin Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjm.v33i2.59288

Keywords:

parathormone, vitamin D deficiency, prediabetes, impaired glucose tolerance, cardiovascular risk factors

Abstract

Introduction: Secondary hyperparathyroidism due to vitamin D deficiency (VDD) is thought to play a role in glucose homeostasis. The aim of this study was to determine the association of parathormone and vitamin D with prediabetes and its different cardiovascular risk factors.

Methods: This crosssectional study was conducted among 117 adults with newly detected prediabetes. Participants were recruited consecutively from the Department of Endocrinology, BSMMU to measure serum 25- hydroxyvitamin D by high performance liquid chromatography, intact parathormone (iPTH) by chemiluminescent enzyme-labeled immunometric assay; fasting insulin by chemiluminescent microparticle immunoassay and glucose by glucose oxidase method to calculate homeostasis model assessment of insulin resistance (HOMA-IR).

Results: Patients with hyperparathyroidism had significantly higher percentages of VDD than those with normal parathyroid status. Only percentages of impaired glucose tolerance (IGT) status had significant association with the combined iPTH and vitamin D groups. Serum iPTH significantly correlated with age, HbA1C, vitamin D and HOMA-IR. Hyperparathyroidism had significant predictive association with only IGT and hypovitaminosis D in adults with prediabetes.

Conclusion: VDD combined with high PTH may be associated with glycemic dysregulation in adults with prediabetes especially in IGT without any significant associations with its cardiovascular risk factors.

Bangladesh J Medicine 2022; 33: 154-160

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Published

2022-04-27

How to Cite

Morshed, M. S. ., hossain, M. F., Ghani, M. H. ., Faisal, I. ., Haq, T. ., Selim, S. ., & Fariduddin, M. (2022). Vitamin D Deficiency Associated Hyperparathyroidism May Be Related With Impaired Glucose Tolerance Without Any Associations With Cardiovascular Risk Factors. Bangladesh Journal of Medicine, 33(2), 154–160. https://doi.org/10.3329/bjm.v33i2.59288

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Original Articles