Bangladesh Journal of Infectious Diseases <p>Published by the Bangladesh Infection Research Association. Full text articles will be available.</p> <p>This journal invites authors and reviewers to register with the journal. The online submission process is available for new submissions.</p> <p><strong>Indexed/Abstract in: </strong>ROAD (; Open DOAR, Directory of Open Access Scholars Repository; ResearchBib; BASE (Bielefeld Academic Search Engine); Academic Resource Index;;; Infobase Index; Eurasian Scientific Journal Index; International Committee for Medical Journal Editors (ICJME); Easy Bib; Google Scholar; AsiaJol; Open Science Directory; EBSCO Information Service; EBSCO Open Access Journals; Hasselt University Library; Islamic Science Index (ISI); World Association of Medical Editors (WAME); Journal Factor; International Institute of Organized Research (I2OR); Impact Factor Services for International Journals (IFSIJ); Open Access Library; Scientific Indexing Services (SIS)</p> <p>&nbsp;</p> en-US <p class="default"><strong>Copyright</strong></p><p>Copyright on any research article in the Bangladesh Journal of Infectious Diseases is retained by the author(s).</p><p>The authors grant the Bangladesh Infection Research Association a license to publish the article and identify itself as the original publisher.</p><p>Articles in the Bangladesh Journal of Infectious Diseases are Open Access articles published under the Creative Commons CC BY-NC License (<a href=""></a>)</p><p>This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.</p> (Dr M Abdullah Yusuf) (Md Fahmid Uddin Khondoker) Tue, 24 Mar 2020 13:20:32 +0000 OJS 60 Chikungunya Fever and Its Impact: Bangladesh Perspective <p>Abstract not available</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):28</p> Sazzad Bin Shahid ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000 Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial <p>&nbsp;</p> <p><strong>Background: </strong>Post-operative infection can occur after bone grafting among patietns with jaw cyst.</p> <p><strong>Objective: </strong>The purpose of the present study was to compare the rate of infection as postoperative outcomes after hydroxyapatite and allogenic bone graft among jaw cyst patients.</p> <p><strong>Methodology: </strong>This randomized clinical trial was conducted in the Department of Oral and Maxillofacial Surgery at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2006 to June 2008. Patients presented with radicular and dentigerous cyst and relatively non infected cystic lesion were selected as study population. The study population were divided into two groups designed as Group A treated with with allogenic-bone graft and Group B treated with hydroxyapatite alloplastic material after enucleation of the cystic lesion. The rate of infection was recorded after surgery in both group A and B.</p> <p><strong>Result: </strong>A total number of 28 patients were recruited for this study of which 14 patients were treated with hydroxyapatite crystals bone graft in group A and 14 patients were treated with allogenic bone graft in group B. Post-operative infection was not found in group A and 5(35.7%) in group B (p&lt;0.05). Infection occurred in 1(20.0%) case in one side intact and 4(80.0%) in both side lost. Infection was found in 1(20.0%) case and 4(80.0%) cases in average and poor oral hygiene status respectively.</p> <p><strong>Conclusion: </strong>In conclusion more infection occurs in allogenic bone graft group than the group treated with hydroxyapatite alloplastic material</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):29-33</p> Showkat Mamun, Ismat Ara Haider, - Nasiruddin, Tarin Rahman, Sheikh Mohammad Jahidul Islam, Farah Diba ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000 Role of Interleukin-6 and Interleukin-8 Cytokines as Early Diagnostic Markers of Sepsis <p><strong>Background: </strong>Rapid diagnosis is essential for effective therapy among the patients with sepsis.</p> <p><strong>Objectives: </strong>The purpose of the present study was to determine the relationship of serum levels of IL-6, IL-8 in patients with various stages of sepsis.</p> <p><strong>Methodology: </strong>This case control study was conducted in the Department of Immunology at Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka from January 2015 to December 2015 for a period of one (01) year. All patients had been selected from the ICU of BIRDEM General Hospital with known clinicopathological parameters of sepsis. Serum levels of IL-6 and IL-8 were assessed using Enzyme Linked Immunosorbent Assay (ELISA) method.</p> <p><strong>Results: </strong>In this study, a total of 80 subjects was enrolled of which 60 patients were with at least 2 SIRS criteria and 20 healthy age matched controls without SIRS. Significant difference was found in IL-6 and IL-8 values in the patients with bacteriological culture positive and negative group (p&lt;0.05). AUC for IL-6 was 0.710 (95% CI 0.580-0.840), sensitivity 54.16%, specificity 59.09%, PPV 74.28% and NPV 52% with cutoff value &gt;177pg/ml.</p> <p><strong>Conclusion: </strong>Elevated levels of serum IL-6 and IL-8 is found in the patients with sepsis</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):34-38</p> Mohammad Moniruzzaman, Ashesh Kumar Chowdhury, ASM Areef Ahsan, Md Zakiur Rahman, Saimun Nahar Rumana, Md Abdullah Yusuf, Gobindo Chandra Saha ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000 Role of HLA-DRB1*13 Allele as a Recovery Factor Among Acute Hepatitis B than Chronic Hepatitis B Infected Patients: A Comparative Study from Bangladesh <p><strong>Background: </strong>The course of hepatitis B virus (HBV) infection is not only determined by variations in viral virulence but may be influenced by host immune response, where Human Leukocyte Antigen (HLA) plays an important role.</p> <p><strong>Objective: </strong>The purpose of the present study was to explore whether HLA-DRB13* allele of MHC gene had any influence in spontaneous recovery from HBV infection among Bangladeshi adults.</p> <p><strong>Method: </strong>This cross sectional study was carried out at the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Bangladesh. A total of 90 randomly selected hepatitis B virus infected adult patients, consisting of 30 acute HBV infections, 30 chronic HBV infection and 30 healthy controls were selected according to selection criteria for evaluation of HLA DRB1*13 allele. Detection of HLA DRB1*13 allele was done by conventional PCR followed by agarose gel electrophoresis.</p> <p><strong>Result: </strong>The study revealed a significant increase of DRB1*13 in acute hepatitis B (AHB vs HC-40% vs 6.7%, RR= 9.4; P value &lt;0.05, AHB vs CHB=40% vs 10%; RR=2.27, P value &lt;0.05) compared to chronic hepatitis B infected (HBV) patients and healthy controls (CHB vs HC-10% vs 6.7%, RR= 1.5, P&gt;0.05). This is the first report on HLA DRB1* gene associations among hepatitis B (HBV) infected Bangladeshi patients.</p> <p><strong>Conclusion: </strong>The present study revealed that HLA DRB1*13 was associated with protection against persistent HBV infection among acutely infected adult HBV patients in Bangladesh.</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):39-43</p> Rokshana Akhter, Afzalunnessa Shirin, Shahina Tabassum, Murad Hossen ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000 Socio-demographic Characteristics of Acute Appendicitis Patients attended at a Tertiary Care Teaching Hospital in Bangladesh <p><strong>Background: </strong>Acute appendicitis can cause morbidity in a large number of people.</p> <p><strong>Objective: </strong>The purpose of the present study was to see the socio-demographic characteristics of acute appendicitis patients.</p> <p><strong>Methodology: </strong>This descriptive cross sectional study was conducted in the Department of Surgery at Rajshahi Medical College Hospital, Rajshahi, Bangladesh from July 2009 to June 2011 for a period of two years. Patients admitted with features of uncomplicated and complicated acute appendicitis (gangrenous or perforated) underwent emergency appendectomy by grid iron incision in all the units of surgery were selected as study population. All clinical information including history, physical findings and investigation reports were collected and recorded in a pre-designed data collection sheet.</p> <p><strong>Result: </strong>A total number of 200 acute appendicitis patients were recruited for this study. Most of the study population were in the age group of 13 to 20 years of age group which was 84(42.0%) cases. The ratio of male and female was 1:1.04. Married were more than unmarried which was 114(57.0%) cases and 86(43.0%) cases respectively. Majority patients of this study was from middle class which was 160(80.0%) cases. Most of the acute appendicitis patients were presented with uncomplicated status which was 136(68.0%) cases and the rest 64(32.0%) cases were in complicated state.</p> <p><strong>Conclusion: </strong>In conclusion most of the acute appendicitis patients are young age female coming from middle class family.</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):44-47</p> ABM Mir Mubinul Islam, Nasima Akhter, Md Zafar Imam, Mafiur Rahman, Jalal Uddin Mohammad Rumi ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000 Pneumococcal Carriage Recovered from Healthy Children and Their Possible Association with Some Risk Factors in Outpatient Department of a 1000 bedded Tertiary Care Hospital at Dhaka City <p><strong>Background: </strong>Detection and monitoring of nasopharyngeal carriage of Streptococcus pneumoniae is important to assess the impact and effectiveness of pneumococcal vaccine programs.</p> <p><strong>Objective: </strong>The aims of this study were to assess the nasopharyngeal colonization rate, investigate some of the risk factors for nasopharyngeal colonization with S. pneumoniae from healthy children.</p> <p><strong>Methodology: </strong>The study was conducted in the department of microbiology of Dhaka Medical College Hospital (DMCH). Data were collected among 200 under five healthy children in different age group (13 months to 36 months), from different socioeconomic status with cramped housing condition from Pediatric OPD of Dhaka Medical College Hospital. S. pneumoniae were isolated and identified by culture, Gram staining, biochemical test and polymerase chain reaction (PCR).</p> <p><strong>Result: </strong>Out of 200 nasopharyngeal swabs, 67 (33.50%) were found to be carriers positive by culture and 92(46%) by PCR. The carrier rate was higher among 13 months to 36 months, low and middle socio-economic groups and among with cramped housing condition.</p> <p><strong>Conclusion: </strong>In conclusion various factors may affect the nasopharyngeal colonization with S. pneumoniae including early age of life, different socio-economic and living condition.</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):48-52</p> Moonmoon Shormin, SM Shamsuzzaman, Md Eunus Ali Mondol, Samira Afroz, Asif Rashed ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000 Hand Foot and Mouth Disease (HFMD) in a 3 Years Old Boy in Bangladesh: A Case Report <p>Hand, foot &amp; mouth disease (HFMD) is a contagious and emerging infectious disease caused by picorna viridae family. It was first reported in New Zealand in 1957 is caused by Coxsackie virus A16 (CVA16), human enterovirus 71 (HEV71) and occasionally by Coxsackie virus A6 and Coxsackie virus A10, are also associated with HFMD and herpangina. Though only small scale outbreaks have been reported from United States, Europe, Australia Japan and Brazil for the first few decades, since 1997 the disease has noticeably changed its character as noted in different Southeast Asian countries. In recent years Bangladesh also faces some cases of HFMD. Though HFMD is a mild disease but in rare cases may develop neurological complications. Early detection and good clinical assessment can prevent the fatal progression and also can reduce morbidity and mortality regarding HFMD.</p> <p>Bangladesh Journal of Infectious Diseases 2019;6(2):53-55</p> Arifa Akram, Lubana Akram ##submission.copyrightStatement## Fri, 20 Mar 2020 00:00:00 +0000