@article{Moinuddin_Rahman_Akhter_Kawser_2010, title={Predictors of Childhood Intractable Epilepsy- A Retrospective Study in A Tertiary Care Hospital}, volume={33}, url={https://www.banglajol.info/index.php/BJCH/article/view/5669}, DOI={10.3329/bjch.v33i1.5669}, abstractNote={<p><strong>Objective:</strong> To study the predictors of intractable childhood epilepsy and to compare<br />the predictors of outcome in early and late onset childhood epilepsy.<br /><strong>Design: </strong>Retrospective study.<br /><strong>Study place:</strong> Child Development and Neurology Unit in the Department of Paediatrics<br />of Bangabandhu Sheikh Mujib Medical University (BSMMU).<br /><strong>Study period: </strong>January 2004 to December 2005.<br /><strong>Subjects:</strong> Children with epilepsy of 1 month to 15 years of age who attended the<br />epilepsy clinic.<br /><strong>Results:</strong> The predictors of outcome of childhood epilepsy were analyzed. According<br />to outcome there were two groups, well- controlled group (seizure free for more than 6<br />months) and intractable epilepsy ( one or more seizures per month over a period of 6<br />months). The predictors of early and late onset childhood epilepsy were also compared.<br />Total 73 cases were studied. Out of them 38 patients had early onset epilepsy (less<br />than one year) and 35 had late onset epilepsy (more than one year). Median age of<br />onset of early and late onset of childhood epilepsy group was 3.5 months and 60<br />months respectively. Male and female ratio was 1.53:1 and 0.94:1 in early and late<br />onset group respectively. Major seizure type was tonic-clonic seizure in 57.9% and<br />77.1% patients of early and late onset group respectively. In this study, 27 (77.1%)<br />patients of late onset and 5(13.2%) patients of early onset group achieved seizure<br />remission. Independent predictors of intractable childhood epilepsy were finally found.<br /><strong>Conclusion:</strong> In this study symptomatic epilepsy, myoclonic seizure, initial high<br />frequency of seizure, infantile spasm, neonatal seizures and birth asphyxia were<br />significantly higher among early onset group than in late onset group. Early onset of<br />seizure, myoclonic seizure, initial high frequency of seizure (≥1 seizure/day),<br />symptomatic etiology, neonatal seizure and microcephaly were found independent<br />predictors of intractable epilepsy.</p><p><strong>Key words:</strong> Early onset; late onset; intractable seizures.<br /><br />DOI: 10.3329/bjch.v33i1.5669<br /><em><br />Bangladesh Journal of Child Health</em> 2009; Vol.33(1): 6-15</p>}, number={1}, journal={Bangladesh Journal of Child Health}, author={Moinuddin, AKM and Rahman, MM and Akhter, S and Kawser, CA}, year={2010}, month={Aug.}, pages={6–15} }