Neonatal Seizures: Correlation between Clinico-Etiological Profile and EEG Findings

  • Ruma Parvin Assistant Professor, Institute of Child Health & Shishu Sasthya Foundation Hospital
  • AFM Salim Professor of Paediatrics, Institute of Child Health & Shishu Sasthya Foundation Hospital
  • Mizanur Rahman Professor and Head, Dept. of Paediatric Neurology, BSMMU
  • Kona Chowdhury Assistant Professor, Dept. of Paediatrics, Ad-din Women?s Medical College and Hospital
  • Azmeri Sultana Assistant Professor, Institute of Child Health & Shishu Sasthya Foundation Hospital
  • Shafi Ahmed Assistant Professor, Dept. of Paediatrics, Northern International Medical College, Dhaka.
  • KM Ziaur Rahman Resident, Dept. of Neurosurgery, Holy Family Red Crescent Medical College and Hospital.

Abstract

Introduction: Seizures are quite common in newborn babies. Among other investigations, EEG is used to show the type and location of the activity in the brain during a seizure. Correlation between clinico-etiological profile of neonatal seizures and EEG findings, so far, has not been studied in Bangladesh.

Objective: The objective of the study was to correlate the clinical, etiological and EEG profile of neonatal seizures.

Methodology: It was a cross-sectional study done at NICU of BSMMU and Central Hospital Ltd. All the neonates admitted with seizures during the study period were included in the study. Their clinico-etiological profiles were carefully recorded and EEG were done in all the cases. Chi-square test was done to find out the statistical difference.

Results: Among total 51 cases of neonatal seizures, 29 (56.86%) cases had perinatal asphyxia, followed by septicemia in 8 (15.67%) and meningitis in 6 (11.76%). Hypoglycemia and hypocalcaemia was found in 10 (19.6%) & 8 (15.7%) cases respectively and 15 (29.4%) had acidosis. Thirty seven (72.5%) patients had seizure within 3rd day of life. Seizures were found tonic in nature in 23(45.1%) cases and subtle 18 (35.3%) cases. EEG findings were abnormal in 22 (43.1%) cases. EEG findings were analyzed with the etiology of seizures and it was found that there was a significant relationship between EEG changes and perinatal asphyxia (p<.0001), septicemia (p<.05), meningitis (p<.01) and neurometabolic disorder (p<.0001). However, no statistical significant relationship between type of discharges of EEG and type (p>.05) & pattern of seizures (p>.05) was found.

Conclusion: This study suggests that there is a significant statistical relationship between EEG findings with perinatal asphyxia, septicemia and meningitis, but no relationship with types and pattern of seizures.

DOI: http://dx.doi.org/10.3329/bjch.v38i1.20023

Bangladesh J Child Health 2014; VOL 38 (1) : 19-23

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Abstract
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Published
2014-08-16
How to Cite
Parvin, R., Salim, A., Rahman, M., Chowdhury, K., Sultana, A., Ahmed, S., & Rahman, K. (2014). Neonatal Seizures: Correlation between Clinico-Etiological Profile and EEG Findings. Bangladesh Journal of Child Health, 38(1), 19-23. https://doi.org/10.3329/bjch.v38i1.20023
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Original Articles