TY - JOUR AU - Mondal, DK AU - Moinuddin, MMA AU - Saha, MM AU - Khanom, AM AU - Yousuf, BMA AU - Talukder, MSA AU - Ara, S PY - 2009/08/11 Y2 - 2024/03/29 TI - Effect of Fenugreek (Methi) on Cortical Thickness of the Thymus in Streptozotocin-Induced Diabetic Rats JF - Bangladesh Journal of Anatomy JA - Bangla. J. Anat. VL - 7 IS - 1 SE - Articles DO - 10.3329/bja.v7i1.3017 UR - https://www.banglajol.info/index.php/BJA/article/view/3017 SP - 37-41 AB - <p><strong>Objective: </strong>To find out microscopically whether Trigonella foenumgraecum (fenugreek seeds/methi seeds) has got any preventive role against the lowering of cortical thickness of the thymic lobules in diabetes mellitus. <br /> <strong>Design: </strong>An experimental study on Long Evans rats which were divided into three equal groups depending on their different shorts of dietary feeding and drug treatment. <br /> <strong>Setting: </strong>Anatomy department of IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in diabetes, Endocrine &amp; Metabolic Disorders). <br /> <strong>Subjects: </strong>Fifty eight healthy young Long Evans rats of either sex weighing 72 to 174gm aged between 50 to 60 days were used in this study. <br /> <strong>Main outcome measures: </strong>Variation of cortical thickness of the thymic lobules in different groups of rat. <br /> <strong>Result: </strong>Cortical thickness in the nondiabetic control group, which ranges from 30.17 to 36.99. and the mean was 34.83 &plusmn; 0.60. In diabetic control group the cortical thickness ranges from 17.78 to 26.46 and the mean was 21.85 &plusmn; 1 On the other hand, in the fenugreek- treated diabetic rats the cortical thickness ranges from 25.71 to 32.95 and mean cortical thickness was 30.49 &plusmn; 0.75. <br /> <strong>Conclusion: </strong>Fenugreek showed a tendency of acting against lowering of the cortical thickness of the thymic lobule of Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing fenugreek as a safe, useful effective agent to preserve the cortical thickness improving the diabetic condition by acting as antidiabetogenic agent.</p> <p><strong>Key words: </strong>Diabetes mellitus, Differential lymphocyte count, Fenugreek, Thymus &nbsp;</p> <p>doi: 10.3329/bja.v7i1.3017</p> <p><em>Bangladesh</em><em> Journal of Anatomy</em> January 2009, Vol. 7 No. 1 pp. 37-41</p> ER -