Hypokalemic Periodic Paralysis: Reports of Two Cases and Brief Review

  • AKM Monwarul Islam Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka
  • Sharadindu Shekhar Roy Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka
  • Shahana Zaman Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka
  • Farhana Ahmed Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka
  • Muhammad Abdur Rahim Department of Nephrology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka
  • Humayra Jesmin Department of Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka
Keywords: Autosomal dominant, channelopathy, hypokalemic periodic paralysis

Abstract

Hypokalemic periodic paralysis (HPP) is a rare autosomal dominant channelopathy characterized by skeletal muscle weakness or paralysis when there is a fall in potassium levels in blood. Weakness may be mild and limited to certain muscle groups or more severe causing generalized paralysis. During an attack, reflexes may be diminished or absent. Attacks may last for a few hours or persist for several days, ultimately resulting in complete recovery. Some patients may develop chronic muscle weakness later in life. Recurrent muscle weakness accompanied by hypokalemia and exclusion of other causes help establish the diagnosis. Potassium supplementation is the mainstay of treatment of acute illness. Lifestyle modification with or without pharmacotherapy in the form of carbonic anhydrase inhibitors and/ or spironolactone can prevent future attacks. Here, we present two cases of HPP, the first one had no positive family history and responded to oral potassium and spironolactone, while the second case had family history suggestive of HPP and was managed with potassium and eplerenone.

Birdem Med J 2019; 9(1): 74-79

Downloads

Download data is not yet available.
Abstract
41
PDF
36

Author Biographies

AKM Monwarul Islam, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka

Department of Cardiology

Sharadindu Shekhar Roy, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka

Department of Cardiology

Shahana Zaman, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka

Department of Cardiology

Farhana Ahmed, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka

Department of Cardiology

Muhammad Abdur Rahim, Department of Nephrology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka

Department of Nephrology

Humayra Jesmin, Department of Nephrology, National Institute of Kidney Diseases & Urology (NIKDU), Dhaka

Department of Nephrology

Published
2019-01-12
How to Cite
Islam, A., Roy, S., Zaman, S., Ahmed, F., Rahim, M. A., & Jesmin, H. (2019). Hypokalemic Periodic Paralysis: Reports of Two Cases and Brief Review. BIRDEM Medical Journal, 9(1), 74-79. https://doi.org/10.3329/birdem.v9i1.39729
Section
Review Articles