Hepatitis B and Hepatitis C Virus Infection among End Stage Renal Disease Patients on Maintenance Hemodialysis, Their Family Members and Dialysis Staffs - A Prevalence Study

  • Rana Mokarram Hossain Associate Professor, Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • M Masud Iqbal Associate Professor, Department of Nephrology, Sir Salimullah Medical College (SSMC), Dhaka
  • Zeenat Farzana Rahman Senior Research Officer, Department of Immunology, Bangladesh Institute of Research and Rehabilitation in Endocrine and Metabolic Disorders (BIRDEM) Hospital, Dhaka
  • Rosy Sultana Associate Professor, Department of Immunology, Bangladesh University of Health Sciences (BUHS), Dhaka
  • Md Habibur Rahman Ex-Professor, Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Md Nazrul Islam Ex-Professor, Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Nazmun Nahar Khan Research Assistant, Department of Immunology, BIRDEM Hospital, Dhaka
  • Md Abul Mansur Professor, Department of Nephrology, BIRDEM Hospital, Dhaka
  • Md Anisur Rahman Associate Professor, Department of Nephrology, BIRDEM Hospital, Dhaka
  • Sarwar Iqbal Professor, Department of Nephrology, BIRDEM Hospital, Dhaka
  • M Sawkat Hassan Professor, Department of Laboratory Services, Ali Asgor Hospital, Dhaka
Keywords: Hepatitis B virus, Hepataitis C Virus, Infection, first degree relative, hospital staff

Abstract

Background: Hepatitis B (HBV) and hepatitis C virus (HCV) infection is common among patients on maintenance hemodialysis (MHD). This study was undertaken to observe prevalence of hepatitis B and C infection in hemodialysis patients, their family members and dialysis staffs.

Methods: In this cross-sectional study 3 groups were included as gr-1 patients on MHD, the first-degree relatives in gr-2 and the dialysis staffs as gr-3. Clinical and laboratory investigations were done. Viral serology included hepatitis B surface antigen (HBsAg) and antibody against hepatitis C virus (anti-HCV) done by enzyme linked immunosorbent sorbent assay (ELISA) method.

Results: Total 150 subjects were analyzed where 50 were in gr-1, 60 gr-2 and 40 in gr-3. In gr-1 MHD patients, HBV infection was positive in 12% and HCV in 71%. None of the viral markers were positive in family members and dialysis staffs. Blood transfusion (BT) was taken by 76% MHD patents. The frequency of HBV and HCV infection was of similar pattern in both BT dependent and non BT group (P=NS).When HCV positive and negative patents were (71 vs. 29%, p<0.001) compared, dialysis duration (37 ± 34 vs. 11± 6 months, p<0.001) was found higher in positive patients.

Conclusion: This survey on dialysis patients showed that prevalence of hepatitis B and C virus infections was higher in Bangladeshi patients on MHD groups. Horizontal spread of these viruses is negligible in caregivers and dialysis staffs.

Birdem Med J 2018; 8(1): 42-46

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Abstract
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Published
2017-12-27
How to Cite
Hossain, R., Iqbal, M. M., Rahman, Z., Sultana, R., Rahman, M. H., Islam, M. N., Khan, N., Mansur, M. A., Rahman, M. A., Iqbal, S., & Hassan, M. S. (2017). Hepatitis B and Hepatitis C Virus Infection among End Stage Renal Disease Patients on Maintenance Hemodialysis, Their Family Members and Dialysis Staffs - A Prevalence Study. BIRDEM Medical Journal, 8(1), 42-46. https://doi.org/10.3329/birdem.v8i1.35038
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Original Articles