Antihyperlipidemic and renoprotective activities of methanolic extract of Canscora decussata extract in alloxan-induced diabetic rabbits

Nadeem Irshad, Muhammad Shoaib Akhtar, Yousaf Kamal, Muhammad Imran Qayyum, Abdul Malik, Rashid Hussain

Abstract

The current study was designed to evaluate the hypolipidemic and renopro-tective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, albumin, globulin and total proteins were estimated by using commercially available kits. The results showed that extract significantly (p<0.01) decreased the raised parameters including triglyceride, total cholesterol and LDL-cholesterol, atherogenic index, Coronary risk index up to normal values compared to diabetic rabbits. However, it significantly increased HDL-cholesterol, albumin, globulin and total protein levels. Therefore, it is suggested that methanolic extract of C. decussata exerts hypolipidemic and renoprotective effects in the alloxan-induced diabetic rabbits.

Keywords

Alloxan; Atherogenic index; Canscora decussata; Coronary risk index; Antihyperlipidemic; Renoprotective

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DOI: http://dx.doi.org/10.3329/bjp.v8i3.15506

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Copyright (c) 2013 Nadeem Irshad, Muhammad Shoaib Akhtar, Yousaf Kamal, M. Imran Qayyum, Abdul Malik, Hafiz Rashid Hussain

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Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is a single-blinded peer-reviewed, video component, open access official publication of the Bangladesh Pharmacological Society (BDPS). eISSN: 1991-0088. For contact: Editor-In-Chief