Characterization of Antimicrobial, Antioxidant, Anticancer Property and Chemical Composition of <i>Michelia champaca</i> Seed and Flower Extracts

Authors

  • Lee Seong Wei Department of Agro Industry, Faculty of Agro Industry and Natural Resources, Universiti Malaysia Kelantan, Pengkalan Chepa, Kota Bharu, Kelantan
  • Wendy Wee Department of Fisheries Science and Aquaculture, Faculty of Agrotechnology and Food Science, Universiti Malaysia Terengganu, Kuala Terengganu, Terengganu
  • Julius Young Fu Siong Institute of Marine Biotechnology, Universiti Malaysia Terengganu Kuala Terengganu, Terengganu
  • Desy Fitrya Syamsumir Institute of Marine Biotechnology, Universiti Malaysia Terengganu Kuala Terengganu, Terengganu

DOI:

https://doi.org/10.3329/sjps.v4i1.8862

Keywords:

Antioxidant, Anticancer, Antimicrobial, Chemical compound, Michelia champaca

Abstract

This study was carried out to characterize antimicrobial, antioxidant and anticancer activities of Michelia champaca seed and flower extracts. The main objective of the present study was to reveal the medicinal values of M. champaca seed and flower for human uses. Antimicrobial property of M. champaca seed and flower extracts were revealed by using two fold microdilution method whereas antioxidant activity of the extract was determined with DPPH radical scavenging method. The anticancer property of the plant extract was revealed through Colorimetric MTT (tetrazolium) assay. The minimum inhibitory concentration values of M. champaca seed and flower extracts ranged from 15.6 to 125mg/l and 7.8 to 62.5mg/l, respectively in which both of the plant extracts were found can inhibit the growth of all the tested bacterial isolates namely A. hydrophila, E. tarda, E. coli, Flavobacterium sp., Klebsiella sp., P. aeruginosa, Salmonella sp., V. alginolyticus, V. cholerae and V. parahaemolyticus. M. champaca flower extract was able to control the growth of E. tarda, E. coli, Flavobacterium sp., P. aeruginosa and V. cholerae at the concentration of 7.8mg/l whereas A. hydrophila, Klebsiella sp. and V. alginolyticus were failed to grow at the concentration 15.6mg/l. The M. champaca flower extract was also able to control the growth of Salmonella sp. and V. parahaemolyticus at the concentration of 62.5mg/l. At the maximum concentration of M. champaca seed and flower extracts were found can inhibit only 40% of DPPH whereas the IC50 value of M. champaca seed and flower extract against MCF-7 cells was 1.98 ±0.31μg/ml and 1.86 ± 0.21μg/ml, respectively. A total of 9 chemical compounds were successfully identified in M. champaca’s flower extract whereas 37 chemical compounds were found in the leaf extract. The findings of the present study indicated that medicinal values of M. champaca seed & flower extracts in terms of antimicrobial and anticancer are promising.

Key words: Antioxidant; Anticancer; Antimicrobial; Chemical compound; Michelia champaca

DOI: http://dx.doi.org/10.3329/sjps.v4i1.8862

SJPS 2011; 4(1): 19-24

Downloads

Download data is not yet available.
Abstract
3926
PDF
1983

Downloads

How to Cite

Wei, L. S., Wee, W., Siong, J. Y. F., & Syamsumir, D. F. (2011). Characterization of Antimicrobial, Antioxidant, Anticancer Property and Chemical Composition of <i>Michelia champaca</i> Seed and Flower Extracts. Stamford Journal of Pharmaceutical Sciences, 4(1), 19–24. https://doi.org/10.3329/sjps.v4i1.8862

Issue

Section

Research Articles