Fluorescence Spectroscopic Studies of in vitro Interactions of Famotidine and Tapentadol Hydrochloride with Bovine Serum Albumin

Authors

  • Md Rasal Hossain Khan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Asma Rahman Centre for Advanced Research and Sciences (CARS), University of Dhaka, Dhaka-1000
  • Md Zakir Sultan Centre for Advanced Research and Sciences (CARS), University of Dhaka, Dhaka-1000
  • Md Zamil Sultan Department of Electrical and Electronic Engineering, Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v15i1.29187

Keywords:

Famotidine, Tapentadol Hydrochloride, in vitro, bovine serum albumin, fluorescence, spectroscopy

Abstract

The in vitro interactions of Famotidine (FT) and Tapentadol hydrochloride (TAP) with bovine serum albumin (BSA) have been studied by fluorescence emission spectroscopy under different conditions. Quenching constants were determined using the Stern-Volmer equation. Two moles FT bound with 1 mole of BSA at 298 K and 3 mole FT bound with 1 mole of BSA at 308 K in presence of TAP. BSA was used for the study as it shows approximately 76% sequence homology to human serum albumin (HSA).

Dhaka Univ. J. Pharm. Sci. 15(1): 21-26, 2016 (June)

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Author Biography

Md Rasal Hossain Khan, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000



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Published

2016-08-08

How to Cite

Khan, M. R. H., Rahman, A., Sultan, M. Z., Sultan, M. Z., & Rashid, M. A. (2016). Fluorescence Spectroscopic Studies of in vitro Interactions of Famotidine and Tapentadol Hydrochloride with Bovine Serum Albumin. Dhaka University Journal of Pharmaceutical Sciences, 15(1), 21–26. https://doi.org/10.3329/dujps.v15i1.29187

Issue

Vol. 15 No. 1 (2016)

Section

Articles

License

© Dhaka University Journal of Pharmaceutical Sciences

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